Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation.
Caveolin 1
DNA methylation
Impaired glucose regulation
bariatric surgery
Journal
Adipocyte
ISSN: 2162-397X
Titre abrégé: Adipocyte
Pays: United States
ID NLM: 101567863
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
24
2
2021
Statut:
ppublish
Résumé
We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired glucose regulation (IGR), the results were compared to bariatric surgery, considering it an intensive change. Twenty participants with IGR had adipose tissue biopsy and blood collected pre- and post-lifestyle (6 months) intervention; 12 obese patients had subcutaneous fat taken before and after bariatric surgery. RNA/DNA was extracted from all samples and underwent qPCR. DNA was bisulphite converted and 12 CpG sites of Caveolin-1 ( lifestyle intervention resulted in opposite direction changes in fat tissue and blood for Our findings suggest a role for
Identifiants
pubmed: 32125224
doi: 10.1080/21623945.2020.1732513
pmc: PMC7153542
doi:
Substances chimiques
CAV1 protein, human
0
Caveolin 1
0
DNA
9007-49-2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-107Références
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