Multi-scale approaches for the simulation of cardiac electrophysiology: I - Sub-cellular and stochastic calcium dynamics from cell to organ.
Action potential
Calcium handling
Cardiac tissue
Computational modelling
Electrophysiology
Excitation–contraction coupling
Propagation
Spontaneous activity
Journal
Methods (San Diego, Calif.)
ISSN: 1095-9130
Titre abrégé: Methods
Pays: United States
ID NLM: 9426302
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
01
08
2019
revised:
14
02
2020
accepted:
26
02
2020
pubmed:
4
3
2020
medline:
28
9
2021
entrez:
4
3
2020
Statut:
ppublish
Résumé
Computational models of the heart at multiple spatial scales, from sub-cellular nanodomains to the whole-organ, are a powerful tool for the simulation of cardiac electrophysiology. Application of these models has provided remarkable insight into the normal and pathological functioning of the heart. In these two articles, we present methods for modelling cardiac electrophysiology at all of these spatial scales. In part one, presented here, we discuss methods and approaches for modelling sub-cellular calcium dynamics at the whole-cell and organ scales, valuable for modelling excitation-contraction coupling and mechanisms of arrhythmia triggers.
Identifiants
pubmed: 32126258
pii: S1046-2023(19)30225-7
doi: 10.1016/j.ymeth.2020.02.011
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-59Subventions
Organisme : Medical Research Council
ID : MR/M014967/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S03241X/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/16/74/32374
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M014967/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.