The Use of Bivalirudin in Pediatric Cardiac Surgery and in the Interventional Cardiology Suite.
ECMO
anticoagulation
bivalirudin
cardiopulmonary bypass
pediatric cardiac surgery
Journal
Journal of cardiothoracic and vascular anesthesia
ISSN: 1532-8422
Titre abrégé: J Cardiothorac Vasc Anesth
Pays: United States
ID NLM: 9110208
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
18
07
2019
revised:
07
01
2020
accepted:
10
01
2020
pubmed:
5
3
2020
medline:
28
4
2021
entrez:
5
3
2020
Statut:
ppublish
Résumé
Anticoagulation is an essential component for patients undergoing cardiopulmonary bypass or extracorporeal membrane oxygenation and for those with ventricular assist devices. However, thrombosis and bleeding are common complications. Heparin continues to be the agent of choice for most patients, likely owing to practitioners' comfort and experience and the ease with which the drug's effects can be reversed. However, especially in pediatric cardiac surgery, there is increasing interest in using bivalirudin as the primary anticoagulant. This drug circumvents certain problems with heparin administration, such as heparin resistance and heparin-induced thrombocytopenia, but it comes with additional challenges. In this manuscript, the authors review the literature on the emerging role of bivalirudin in pediatric cardiac surgery, including its use with cardiopulmonary bypass surgery, extracorporeal membrane oxygenation, ventricular assist devices, and interventional cardiology. Moreover, they provide an overview of bivalirudin's pharmacodynamics and monitoring methods.
Identifiants
pubmed: 32127273
pii: S1053-0770(20)30081-1
doi: 10.1053/j.jvca.2020.01.020
pmc: PMC7321892
mid: NIHMS1552239
pii:
doi:
Substances chimiques
Anticoagulants
0
Hirudins
0
Peptide Fragments
0
Recombinant Proteins
0
Heparin
9005-49-6
bivalirudin
TN9BEX005G
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2215-2223Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL145132
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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