Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains.
NHBE
influenza
interferons
obesity
viral evolution
virulence
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Obesity is associated with increased disease severity, elevated viral titers in exhaled breath, and significantly prolonged viral shed during influenza A virus infection. Due to the mutable nature of RNA viruses, we questioned whether obesity could also influence influenza virus population diversity. Here, we show that minor variants rapidly emerge in obese mice. The variants exhibit increased viral replication, resulting in enhanced virulence in wild-type mice. The increased diversity of the viral population correlated with decreased type I interferon responses, and treatment of obese mice with recombinant interferon reduced viral diversity, suggesting that the delayed antiviral response exhibited in obesity permits the emergence of a more virulent influenza virus population. This is not unique to obese mice. Obesity-derived normal human bronchial epithelial (NHBE) cells also showed decreased interferon responses and increased viral replication, suggesting that viral diversity also was impacted in this increasing population.
Identifiants
pubmed: 32127459
pii: mBio.03341-19
doi: 10.1128/mBio.03341-19
pmc: PMC7064783
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI140766
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106700
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Informations de copyright
Copyright © 2020 Honce et al.
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