The HIV-1 Accessory Protein Vpu Downregulates Peroxisome Biogenesis.
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
Cell Line
Fatty Acids
/ metabolism
Gene Expression Regulation, Viral
HIV Infections
/ immunology
HIV-1
/ physiology
Host-Pathogen Interactions
Human Immunodeficiency Virus Proteins
/ genetics
Humans
Mutation
Peroxisomes
/ metabolism
Viral Regulatory and Accessory Proteins
/ genetics
HIV
Vpu
miRNAs
peroxisomes
β-catenin
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Human immunodeficiency virus type 1 (HIV-1) establishes lifelong infections in humans, a process that relies on its ability to thwart innate and adaptive immune defenses of the host. Recently, we reported that HIV-1 infection results in a dramatic reduction of the cellular peroxisome pool. Peroxisomes are metabolic organelles that also function as signaling platforms in the innate immune response. Here, we show that the HIV-1 accessory protein Vpu is necessary and sufficient for the depletion of cellular peroxisomes during infection. Vpu induces the expression of four microRNAs that target mRNAs encoding proteins required for peroxisome formation and metabolic function. The ability of Vpu to downregulate peroxisomes was found to be dependent upon the Wnt/β-catenin signaling pathway. Given the importance of peroxisomes in innate immune signaling and central nervous system function, the roles of Vpu in dampening antiviral signaling appear to be more diverse than previously realized. Finally, our findings highlight a potential role for Wnt/β-catenin signaling in peroxisome homeostasis through modulating the production of biogenesis factors.
Identifiants
pubmed: 32127461
pii: mBio.03395-19
doi: 10.1128/mBio.03395-19
pmc: PMC7064786
pii:
doi:
Substances chimiques
Biomarkers
0
Fatty Acids
0
Human Immunodeficiency Virus Proteins
0
Viral Regulatory and Accessory Proteins
0
vpu protein, Human immunodeficiency virus 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : HAL-201803
Pays : Canada
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Xu et al.
Références
Retrovirology. 2010 Dec 22;7:114
pubmed: 21176220
Elife. 2019 Feb 05;8:
pubmed: 30717826
J Infect Dis. 2011 Sep 1;204(5):753-60
pubmed: 21844301
Cell. 2010 May 14;141(4):668-81
pubmed: 20451243
J Virol. 2008 Mar;82(6):2813-20
pubmed: 18199649
J Virol. 2013 Jan;87(2):872-81
pubmed: 23115297
J Virol. 1995 Nov;69(11):7032-44
pubmed: 7474123
Yeast. 1992 Sep;8(9):721-34
pubmed: 1279909
Cell Host Microbe. 2008 Apr 17;3(4):245-52
pubmed: 18342597
Retrovirology. 2014 Feb 06;11:15
pubmed: 24498878
Cell Biosci. 2011 Jan 18;1(1):4
pubmed: 21711587
J Cell Mol Med. 2016 Apr;20(4):750-7
pubmed: 26865163
J Biol Chem. 2001 May 11;276(19):15920-8
pubmed: 11278695
Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):478-85
pubmed: 20717021
PLoS Pathog. 2017 Jun 8;13(6):e1006360
pubmed: 28594894
J Biol Chem. 2004 Jan 2;279(1):788-95
pubmed: 14561767
Nat Cell Biol. 2014 Mar;16(3):268-80
pubmed: 24561623
J Virol. 1992 Dec;66(12):7193-200
pubmed: 1433512
Nat Immunol. 2014 Aug;15(8):717-26
pubmed: 24952503
Annu Rev Biochem. 2006;75:295-332
pubmed: 16756494
Gastroenterology. 2019 Aug;157(2):537-551.e9
pubmed: 30978357
FEBS J. 2014 Sep;281(17):3791-802
pubmed: 25051991
Curr HIV Res. 2014;12(3):164-73
pubmed: 24862328
J Neurosci. 2015 Feb 4;35(5):1921-38
pubmed: 25653352
Blood. 2012 Feb 16;119(7):1623-33
pubmed: 22174153
Lancet Neurol. 2014 Nov;13(11):1139-1151
pubmed: 25316020
J Neuroimmune Pharmacol. 2012 Dec;7(4):731-9
pubmed: 23065461
Mol Cell. 1998 Mar;1(4):565-74
pubmed: 9660940
Traffic. 2011 Mar;12(3):252-9
pubmed: 21083858
J Virol. 1998 Apr;72(4):2855-64
pubmed: 9525605
Cell Host Microbe. 2009 Nov 19;6(5):409-21
pubmed: 19917496
Biochim Biophys Acta. 2010 Mar;1801(3):392-9
pubmed: 19800025
Nitric Oxide. 2013 May 31;31:9-19
pubmed: 23474170
J Clin Invest. 2014 Oct;124(10):4459-72
pubmed: 25202977
Nature. 1988 Aug 11;334(6182):532-4
pubmed: 3043230
Biol Open. 2018 Jan 26;7(1):
pubmed: 29212798
Virology. 2002 Sep 30;301(2):342-53
pubmed: 12359436
Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197
pubmed: 28474989
Clin Infect Dis. 2015 Feb 1;60(3):473-80
pubmed: 25362201
Mol Carcinog. 2004 Nov;41(3):125-39
pubmed: 15457508
Curr Opin Neurol. 2011 Jun;24(3):275-83
pubmed: 21467932
Nature. 2008 Jan 24;451(7177):425-30
pubmed: 18200009
J Virol. 2008 Apr;82(8):3932-8
pubmed: 18256147
Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14590-5
pubmed: 21844353
PLoS Pathog. 2015 Nov 20;11(11):e1005264
pubmed: 26588843
Clin Chim Acta. 1999 Mar;281(1-2):159-62
pubmed: 10217636
Cancers (Basel). 2016 Jul 20;8(7):
pubmed: 27447672
AIDS. 2016 Aug 24;30(13):2021-31
pubmed: 27191977
J Biol Chem. 2014 Jul 11;289(28):19599-612
pubmed: 24855648
Apoptosis. 2014 Jun;19(6):984-97
pubmed: 24699798
Mol Biol Cell. 2018 Feb 15;29(4):396-407
pubmed: 29282281
Nat Rev Mol Cell Biol. 2013 Dec;14(12):803-17
pubmed: 24263361
Dis Model Mech. 2012 Jan;5(1):125-40
pubmed: 21954064
Retrovirology. 2017 Mar 14;14(1):18
pubmed: 28288652
J Cell Sci. 2006 Feb 15;119(Pt 4):636-45
pubmed: 16449325
Science. 1988 Sep 2;241(4870):1221-3
pubmed: 3261888
Biochim Biophys Acta. 2016 May;1863(5):934-55
pubmed: 26686055
J Virol. 2015 Dec;89(24):12349-61
pubmed: 26423946
J Virol. 2012 Sep;86(17):9495-503
pubmed: 22674979
DNA Cell Biol. 2018 May;37(5):417-421
pubmed: 29443540
Neurosci Bull. 2018 Jun;34(3):573-588
pubmed: 29582250
J Mol Biol. 1994 Feb 11;236(1):16-25
pubmed: 8107101
Retrovirology. 2014 May 13;11:35
pubmed: 24886384
Curr Opin Cell Biol. 2018 Apr;51:42-49
pubmed: 29153704
Cell. 2017 Jun 1;169(6):985-999
pubmed: 28575679