Diet modulates brain network stability, a biomarker for brain aging, in young adults.
Adaptation, Physiological
Adolescent
Adult
Aged
Aged, 80 and over
Aging
/ physiology
Brain
/ diagnostic imaging
Cognition
/ physiology
Datasets as Topic
Dementia
/ diet therapy
Diet, Ketogenic
Energy Metabolism
/ physiology
Feeding Behavior
/ physiology
Female
Glucose
/ administration & dosage
Humans
Insulin
/ metabolism
Insulin Resistance
/ physiology
Ketones
/ administration & dosage
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
/ physiology
Neuroimaging
/ methods
Young Adult
beta-hydroxybutyrate
brain
glucose
ketone
neural
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
17 03 2020
17 03 2020
Historique:
pubmed:
5
3
2020
medline:
14
7
2020
entrez:
5
3
2020
Statut:
ppublish
Résumé
Epidemiological studies suggest that insulin resistance accelerates progression of age-based cognitive impairment, which neuroimaging has linked to brain glucose hypometabolism. As cellular inputs, ketones increase Gibbs free energy change for ATP by 27% compared to glucose. Here we test whether dietary changes are capable of modulating sustained functional communication between brain regions (network stability) by changing their predominant dietary fuel from glucose to ketones. We first established network stability as a biomarker for brain aging using two large-scale (
Identifiants
pubmed: 32127481
pii: 1913042117
doi: 10.1073/pnas.1913042117
pmc: PMC7084077
doi:
Substances chimiques
Insulin
0
Ketones
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
6170-6177Subventions
Organisme : NIMH NIH HHS
ID : R24 MH114796
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: The intellectual property covering the uses of ketone bodies and ketone esters is owned by BTG Plc., Oxford University Innovation Ltd., and the NIH. R.L.V. and K.C., as inventors, will receive a share of the royalties under the terms prescribed by each institution. K.C. is a director of TΔS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition. TΔS Ltd. has licensed HVMN Inc. to sell the ketone ester in sports drinks in the United States.
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