C - reactive protein of cerebrospinal fluid, as a sensitive approach for diagnosis of neonatal meningitis.
C-reactive protein
cerebrospinal fluid
diagnostic value
infant
septic/aseptic meningitis
Journal
African health sciences
ISSN: 1729-0503
Titre abrégé: Afr Health Sci
Pays: Uganda
ID NLM: 101149451
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
1
9
2020
Statut:
ppublish
Résumé
Meningitis, is a potentially life-threatening condition that can rapidly progress to permanent brain damage, neurologic problems, and even death. Bacteria and viruses cause the great majority of meningitis disease in infants and children. CRP is used mainly as a marker of inflammation. This study was conducted to assess the diagnostic value of CSF-CRP levels for differentiating between septic (bacterial) and aseptic infantile meningitis. 49 hospitalized infants aged less than two months with suspected meningitis were enrolled in a cross-sectional analytic study. All of patients underwent lumbar puncture to obtain CSF. smears, cultures, cytological and biochemical analysis and latex agglutination testing were carried out on all CSF samples. Latex agglutination test was carried out on all CSF samples using a commercially available kit. CSF-CRP level of all infants was measured using the immunoturbidometric technique. Of 49 infants in this study, 20 and 29 cases were diagnosed as septic and aseptic meningitis, respectively. The CRP levels were obtained as 0.95±0.68 mg/L in septic and 0.16±0.36 mg/L in aseptic meningitis groups and this difference was statistically significant (p<0.001) between the two groups (0.79±0.32 mg/L). Based on the ROC curve, cut off levels for CRP was obtained 0.17 mg/L. At this level, there was 95% sensitivity and 86% specificity to differentiate septic and aseptic meningitis. CSF-CRP has suitable diagnostic value in distinguishing between infantile bacterial from aseptic meningitis especially in cases of negative bacterial culture of the blood and spinal fluid.
Sections du résumé
BACKGROUND
BACKGROUND
Meningitis, is a potentially life-threatening condition that can rapidly progress to permanent brain damage, neurologic problems, and even death. Bacteria and viruses cause the great majority of meningitis disease in infants and children. CRP is used mainly as a marker of inflammation.
OBJECTIVE
OBJECTIVE
This study was conducted to assess the diagnostic value of CSF-CRP levels for differentiating between septic (bacterial) and aseptic infantile meningitis.
METHODS
METHODS
49 hospitalized infants aged less than two months with suspected meningitis were enrolled in a cross-sectional analytic study. All of patients underwent lumbar puncture to obtain CSF. smears, cultures, cytological and biochemical analysis and latex agglutination testing were carried out on all CSF samples. Latex agglutination test was carried out on all CSF samples using a commercially available kit. CSF-CRP level of all infants was measured using the immunoturbidometric technique.
RESULTS
RESULTS
Of 49 infants in this study, 20 and 29 cases were diagnosed as septic and aseptic meningitis, respectively. The CRP levels were obtained as 0.95±0.68 mg/L in septic and 0.16±0.36 mg/L in aseptic meningitis groups and this difference was statistically significant (p<0.001) between the two groups (0.79±0.32 mg/L). Based on the ROC curve, cut off levels for CRP was obtained 0.17 mg/L. At this level, there was 95% sensitivity and 86% specificity to differentiate septic and aseptic meningitis.
CONCLUSION
CONCLUSIONS
CSF-CRP has suitable diagnostic value in distinguishing between infantile bacterial from aseptic meningitis especially in cases of negative bacterial culture of the blood and spinal fluid.
Identifiants
pubmed: 32127807
doi: 10.4314/ahs.v19i3.10
pii: jAFHS.v19.i3.pg2372
pmc: PMC7040284
doi:
Substances chimiques
Biomarkers
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2372-2377Informations de copyright
© 2019 Javadinia et al.
Références
Sultan Qaboos Univ Med J. 2013 Feb;13(1):93-9
pubmed: 23573388
Med Mal Infect. 2009 Jul-Aug;39(7-8):581-605
pubmed: 19398286
Acta Paediatr. 1995 Jan;84(1):10-3
pubmed: 7734887
J Infect. 2011 Apr;62(4):255-62
pubmed: 21382412
J Pediatr. 1981 Jan;98(1):20-4
pubmed: 7452399
Clin Microbiol Rev. 2010 Jul;23(3):467-92
pubmed: 20610819
Eur J Clin Microbiol Infect Dis. 1988 Jun;7(3):374-80
pubmed: 3137038
Clin Infect Dis. 2004 Nov 1;39(9):1267-84
pubmed: 15494903
J Clin Microbiol. 1986 Dec;24(6):982-5
pubmed: 3782462
J Clin Lab Anal. 2015 May;29(3):169-74
pubmed: 24797775
JAMA. 1999 Jul 14;282(2):175-81
pubmed: 10411200
BMJ. 2008 Jan 5;336(7634):36-40
pubmed: 18174598
J Pediatr. 1981 Sep;99(3):365-9
pubmed: 7264788
Indian Pediatr. 1995 Jun;32(6):687-8
pubmed: 8613341
Eur J Neurol. 2008 Jul;15(7):649-59
pubmed: 18582342
JAMA. 2006 Oct 25;296(16):2012-22
pubmed: 17062865
J Immunol Methods. 1987 Jun 26;100(1-2):191-5
pubmed: 3598196
Eur J Pediatr. 1986 Sep;145(4):246-9
pubmed: 3769991
J Lab Clin Med. 1985 Oct;106(4):424-7
pubmed: 4045298
Clin Chem. 1985 Feb;31(2):345
pubmed: 3967387
Curr Top Microbiol Immunol. 1978;80:1-35
pubmed: 352628
Lancet. 1982 May 1;1(8279):980-2
pubmed: 6122844
J Pediatr. 1986 May;108(5 Pt 1):665-70
pubmed: 3701510