IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo.
Allergy
Asthma
Atopic dermatitis
CCD, Cross-reactive carbohydrate determinant
CRD, Component-resolved diagnostics
Child
Cohort
Eczema
HDM, House dust mite
ISAAC
ISAAC, The International Study of Asthma and Allergies in Childhood
ISAC
ISAC, Immuno-solid-phase Allergen Chip
IgE
IgE, Immunoglobulin E
JECS, The Japan Environment and Children's Study
PC, Principal component
PCA, Principal component analysis
PR, Pathogenesis-related
Prospective birth cohort
Rhinitis
Sensitization
UK, The United Kingdom
US, The United States
Wheeze
sIgE, Allergen-specific IgE
Journal
The World Allergy Organization journal
ISSN: 1939-4551
Titre abrégé: World Allergy Organ J
Pays: United States
ID NLM: 101481283
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
17
05
2019
revised:
29
11
2019
accepted:
15
01
2020
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
5
3
2020
Statut:
epublish
Résumé
Response patterns to allergen components among Japanese children have not been studied extensively. Our aim was to examine the differences in sensitization patterns at ages 5 years and 9 years to identify longitudinal changes in the degree and patterns of sensitization in a birth cohort of Japanese children. Our study enrolled 984 children at aged 5 years between 2008 and 2010, and 729 children aged 9 years between 2012 and 2014. Allergic diseases were assessed using the ISAAC and UK Working Party's Diagnostic Criteria. Serum-specific IgE titers to allergen components were measured by multiplex array ImmunoCAP ISAC when the children were aged 5 and 9 years. Principal component analysis (PCA) was performed to characterize IgE sensitization to allergen components. The prevalence of allergic rhinitis increased considerably over time (10.6%-31.2%). Furthermore, the sensitization prevalence to allergen-specific IgE (sIgE) also increased from 57.8% at age 5 years to 74.8% at age 9 years. IgE sensitization prevalence to Der f 1 (mites) was 42.1% at age 5 years and 54.3% at age 9 years. Furthermore, children were highly sensitized to Cry j 1 (Japanese cedar) (32.8% at age 5 years and 57.8% at age 9 years). Principle component analysis showed that sensitization to PR-10 cross-reactive components was independent of sensitization to mite and that no children acquired sensitization to pollen before acquiring sensitization to mite. The prevalence of allergic rhinitis and related allergen components increased from age 5 years to age 9 years in Japanese children.
Sections du résumé
BACKGROUND
BACKGROUND
Response patterns to allergen components among Japanese children have not been studied extensively.
OBJECTIVE
OBJECTIVE
Our aim was to examine the differences in sensitization patterns at ages 5 years and 9 years to identify longitudinal changes in the degree and patterns of sensitization in a birth cohort of Japanese children.
METHODS
METHODS
Our study enrolled 984 children at aged 5 years between 2008 and 2010, and 729 children aged 9 years between 2012 and 2014. Allergic diseases were assessed using the ISAAC and UK Working Party's Diagnostic Criteria. Serum-specific IgE titers to allergen components were measured by multiplex array ImmunoCAP ISAC when the children were aged 5 and 9 years. Principal component analysis (PCA) was performed to characterize IgE sensitization to allergen components.
RESULTS
RESULTS
The prevalence of allergic rhinitis increased considerably over time (10.6%-31.2%). Furthermore, the sensitization prevalence to allergen-specific IgE (sIgE) also increased from 57.8% at age 5 years to 74.8% at age 9 years. IgE sensitization prevalence to Der f 1 (mites) was 42.1% at age 5 years and 54.3% at age 9 years. Furthermore, children were highly sensitized to Cry j 1 (Japanese cedar) (32.8% at age 5 years and 57.8% at age 9 years). Principle component analysis showed that sensitization to PR-10 cross-reactive components was independent of sensitization to mite and that no children acquired sensitization to pollen before acquiring sensitization to mite.
CONCLUSIONS
CONCLUSIONS
The prevalence of allergic rhinitis and related allergen components increased from age 5 years to age 9 years in Japanese children.
Identifiants
pubmed: 32128024
doi: 10.1016/j.waojou.2020.100105
pii: S1939-4551(20)30008-9
pii: 100105
pmc: PMC7044531
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100105Informations de copyright
© 2020 The Author(s).
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