JUNGFRAU detector for brighter x-ray sources: Solutions for IT and data science challenges in macromolecular crystallography.
Journal
Structural dynamics (Melville, N.Y.)
ISSN: 2329-7778
Titre abrégé: Struct Dyn
Pays: United States
ID NLM: 101660872
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
27
12
2019
accepted:
04
02
2020
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
5
3
2020
Statut:
epublish
Résumé
In this paper, we present a data workflow developed to operate the adJUstiNg Gain detector FoR the Aramis User station (JUNGFRAU) adaptive gain charge integrating pixel-array detectors at macromolecular crystallography beamlines. We summarize current achievements for operating at 9 GB/s data-rate a JUNGFRAU with 4 Mpixel at 1.1 kHz frame-rate and preparations to operate at 46 GB/s data-rate a JUNGFRAU with 10 Mpixel at 2.2 kHz in the future. In this context, we highlight the challenges for computer architecture and how these challenges can be addressed with innovative hardware including IBM POWER9 servers and field-programmable gate arrays. We discuss also data science challenges, showing the effect of rounding and lossy compression schemes on the MX JUNGFRAU detector images.
Identifiants
pubmed: 32128347
doi: 10.1063/1.5143480
pii: 1.5143480
pmc: PMC7044001
doi:
Types de publication
Journal Article
Langues
eng
Pagination
014305Informations de copyright
© 2020 Author(s).
Références
FEBS J. 2014 Sep;281(18):4046-60
pubmed: 25040949
Acta Crystallogr D Biol Crystallogr. 2012 Jan;68(Pt 1):42-56
pubmed: 22194332
J Synchrotron Radiat. 2018 Mar 1;25(Pt 2):612-617
pubmed: 29488943
IUCrJ. 2019 Aug 17;6(Pt 5):927-937
pubmed: 31576225
J Synchrotron Radiat. 2014 Sep;21(Pt 5):1006-10
pubmed: 25177989
Nat Methods. 2015 Feb;12(2):131-3
pubmed: 25506719
Nat Methods. 2018 Oct;15(10):799-804
pubmed: 30275593
Science. 2019 Jul 5;365(6448):61-65
pubmed: 31273117
Acta Crystallogr D Struct Biol. 2018 Feb 1;74(Pt 2):85-97
pubmed: 29533234
Acta Crystallogr D Biol Crystallogr. 1999 Oct;55(Pt 10):1703-17
pubmed: 10531520
Methods Mol Biol. 2017;1607:239-272
pubmed: 28573576
Philos Trans A Math Phys Eng Sci. 2019 Jun 17;377(2147):20180241
pubmed: 31030653
Nat Methods. 2019 Oct;16(10):979-982
pubmed: 31527838
J Synchrotron Radiat. 2020 Mar 1;27(Pt 2):329-339
pubmed: 32153271
Nat Methods. 2014 May;11(5):545-8
pubmed: 24633409
J Appl Crystallogr. 2015 Jan 30;48(Pt 1):301-305
pubmed: 26089752
Curr Opin Struct Biol. 2015 Oct;34:60-8
pubmed: 26209821
Acta Crystallogr D Struct Biol. 2019 Mar 1;75(Pt 3):242-261
pubmed: 30950396
J Appl Crystallogr. 2011 Dec 1;44(Pt 6):1285-1287
pubmed: 22477786
Nature. 2014 Sep 11;513(7517):261-5
pubmed: 25043005
Acta Crystallogr D Struct Biol. 2016 Sep;72(Pt 9):1036-48
pubmed: 27599736
Nature. 2011 Feb 3;470(7332):73-7
pubmed: 21293373
Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):352-67
pubmed: 22505256
J Synchrotron Radiat. 2015 May;22(3):577-83
pubmed: 25931071
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692