Pencil beam scanning proton therapy of Hodgkin's lymphoma in deep inspiration breath-hold: A case series report.
Deep inspiration breath-hold
Hodgkin’s lymphoma
Pencil beam scanning
Proton therapy
Radiotherapy
Journal
Technical innovations & patient support in radiation oncology
ISSN: 2405-6324
Titre abrégé: Tech Innov Patient Support Radiat Oncol
Pays: England
ID NLM: 101762366
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
18
06
2019
revised:
14
11
2019
accepted:
15
11
2019
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
5
3
2020
Statut:
epublish
Résumé
Most patients with Hodgkin's lymphoma are young and have a favourable prognosis, therefore it is of high importance to decrease the radiation doses to normal tissues received during radiotherapy. A combination of proton therapy and deep inspiration breath-hold technique (DIBH) can improve the sparing effect and thereby reduce the risk of late effects. The two first patient cases treated with proton therapy in DIBH at the Skandion Clinic, Uppsala, Sweden, are presented here. Proton treatment plans were compared to photon plans based on doses to target and organs at risk. Several CT scans were acquired during the treatment course and inter breath-hold variations were evaluated based on anatomical distances and dosimetric comparisons. The results from our first patients treated with proton therapy in DIBH imply that the treatment strategy is robust and has the potential to reduce dose to normal tissue.
Sections du résumé
BACKGROUND
BACKGROUND
Most patients with Hodgkin's lymphoma are young and have a favourable prognosis, therefore it is of high importance to decrease the radiation doses to normal tissues received during radiotherapy. A combination of proton therapy and deep inspiration breath-hold technique (DIBH) can improve the sparing effect and thereby reduce the risk of late effects.
CASE PRESENTATION
METHODS
The two first patient cases treated with proton therapy in DIBH at the Skandion Clinic, Uppsala, Sweden, are presented here. Proton treatment plans were compared to photon plans based on doses to target and organs at risk. Several CT scans were acquired during the treatment course and inter breath-hold variations were evaluated based on anatomical distances and dosimetric comparisons.
CONCLUSIONS
CONCLUSIONS
The results from our first patients treated with proton therapy in DIBH imply that the treatment strategy is robust and has the potential to reduce dose to normal tissue.
Identifiants
pubmed: 32128456
doi: 10.1016/j.tipsro.2019.11.006
pii: S2405-6324(19)30026-5
pmc: PMC7042155
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6-10Informations de copyright
© 2019 The Author(s).
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
Références
Phys Med Biol. 2014 Jul 21;59(14):3813-28
pubmed: 24955723
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):534-541
pubmed: 26797540
Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):41-50
pubmed: 28816159
J Clin Oncol. 2002 Apr 15;20(8):2101-8
pubmed: 11956271
Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):825-842
pubmed: 28943076
Acta Oncol. 2006;45(8):1094-101
pubmed: 17118845
Phys Med Biol. 2012 Jun 7;57(11):R99-117
pubmed: 22571913
Acta Oncol. 2019 Jan;58(1):95-104
pubmed: 30280626
J Appl Clin Med Phys. 2018 Jan;19(1):25-38
pubmed: 29139223
Radiother Oncol. 2017 Oct;125(1):41-47
pubmed: 28838605