Quantitative imaging: systematic review of perfusion/flow phantoms.

Microcirculation Perfusion imaging Phantoms (imaging) Reference standards

Journal

European radiology experimental
ISSN: 2509-9280
Titre abrégé: Eur Radiol Exp
Pays: England
ID NLM: 101721752

Informations de publication

Date de publication:
04 03 2020
Historique:
received: 28 03 2019
accepted: 08 11 2019
entrez: 5 3 2020
pubmed: 5 3 2020
medline: 5 5 2021
Statut: epublish

Résumé

We aimed at reviewing design and realisation of perfusion/flow phantoms for validating quantitative perfusion imaging (PI) applications to encourage best practices. A systematic search was performed on the Scopus database for "perfusion", "flow", and "phantom", limited to articles written in English published between January 1999 and December 2018. Information on phantom design, used PI and phantom applications was extracted. Of 463 retrieved articles, 397 were rejected after abstract screening and 32 after full-text reading. The 37 accepted articles resulted to address PI simulation in brain (n = 11), myocardial (n = 8), liver (n = 2), tumour (n = 1), finger (n = 1), and non-specific tissue (n = 14), with diverse modalities: ultrasound (n = 11), computed tomography (n = 11), magnetic resonance imaging (n = 17), and positron emission tomography (n = 2). Three phantom designs were described: basic (n = 6), aligned capillary (n = 22), and tissue-filled (n = 12). Microvasculature and tissue perfusion were combined in one compartment (n = 23) or in two separated compartments (n = 17). With the only exception of one study, inter-compartmental fluid exchange could not be controlled. Nine studies compared phantom results with human or animal perfusion data. Only one commercially available perfusion phantom was identified. We provided insights into contemporary phantom approaches to PI, which can be used for ground truth evaluation of quantitative PI applications. Investigators are recommended to verify and validate whether assumptions underlying PI phantom modelling are justified for their intended phantom application.

Sections du résumé

BACKGROUND
We aimed at reviewing design and realisation of perfusion/flow phantoms for validating quantitative perfusion imaging (PI) applications to encourage best practices.
METHODS
A systematic search was performed on the Scopus database for "perfusion", "flow", and "phantom", limited to articles written in English published between January 1999 and December 2018. Information on phantom design, used PI and phantom applications was extracted.
RESULTS
Of 463 retrieved articles, 397 were rejected after abstract screening and 32 after full-text reading. The 37 accepted articles resulted to address PI simulation in brain (n = 11), myocardial (n = 8), liver (n = 2), tumour (n = 1), finger (n = 1), and non-specific tissue (n = 14), with diverse modalities: ultrasound (n = 11), computed tomography (n = 11), magnetic resonance imaging (n = 17), and positron emission tomography (n = 2). Three phantom designs were described: basic (n = 6), aligned capillary (n = 22), and tissue-filled (n = 12). Microvasculature and tissue perfusion were combined in one compartment (n = 23) or in two separated compartments (n = 17). With the only exception of one study, inter-compartmental fluid exchange could not be controlled. Nine studies compared phantom results with human or animal perfusion data. Only one commercially available perfusion phantom was identified.
CONCLUSION
We provided insights into contemporary phantom approaches to PI, which can be used for ground truth evaluation of quantitative PI applications. Investigators are recommended to verify and validate whether assumptions underlying PI phantom modelling are justified for their intended phantom application.

Identifiants

pubmed: 32128653
doi: 10.1186/s41747-019-0133-2
pii: 10.1186/s41747-019-0133-2
pmc: PMC7054493
doi:

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

15

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Auteurs

Marije E Kamphuis (ME)

Multimodality Medical Imaging M3i Group, Faculty of Science and Technology, Technical Medical Centre, University of Twente, PO Box 217, Enschede, The Netherlands. m.e.kamphuis@utwente.nl.
Robotics and Mechatronics Group, Faculty of Electrical Engineering, Mathematics, and Computer Science, Technical Medical Centre, University of Twente, Enschede, The Netherlands. m.e.kamphuis@utwente.nl.

Marcel J W Greuter (MJW)

Robotics and Mechatronics Group, Faculty of Electrical Engineering, Mathematics, and Computer Science, Technical Medical Centre, University of Twente, Enschede, The Netherlands.
Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Riemer H J A Slart (RHJA)

Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Biomedical Photonic Imaging Group, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

Cornelis H Slump (CH)

Robotics and Mechatronics Group, Faculty of Electrical Engineering, Mathematics, and Computer Science, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

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