Proteome profile of peripheral myelin in healthy mice and in a neuropathy model.
charcot-marie-tooth (cmt) neuropathy
demyelination
mouse
myelin proteome
neuroscience
peripheral nervous system
schwann cell
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
received:
27
08
2019
accepted:
19
02
2020
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
10
4
2021
Statut:
epublish
Résumé
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin. Despite the relevance of the peripheral nervous system for normal sensory and motor capabilities, analogous approaches to peripheral nerves and peripheral myelin have fallen behind evolving technical standards. Here we assess the peripheral myelin proteome by gel-free, label-free mass-spectrometry for deep quantitative coverage. Integration with RNA-Sequencing-based developmental mRNA-abundance profiles and neuropathy disease genes illustrates the utility of this resource. Notably, the periaxin-deficient mouse model of the neuropathy Charcot-Marie-Tooth 4F displays a highly pathological myelin proteome profile, exemplified by the discovery of reduced levels of the monocarboxylate transporter MCT1/SLC16A1 as a novel facet of the neuropathology. This work provides the most comprehensive proteome resource thus far to approach development, function and pathology of peripheral myelin, and a straightforward, accurate and sensitive workflow to address myelin diversity in health and disease.
Identifiants
pubmed: 32130108
doi: 10.7554/eLife.51406
pii: 51406
pmc: PMC7056269
doi:
pii:
Substances chimiques
Membrane Proteins
0
Myelin Proteins
0
Proteome
0
periaxin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : WE 2720/2-2
Organisme : Deutsche Forschungsgemeinschaft
ID : WE 2720/4-1
Organisme : Deutsche Forschungsgemeinschaft
ID : WE 2720/5-1
Organisme : Deutsche Forschungsgemeinschaft
ID : RO 4076/3-2
Organisme : Wellcome
ID : 0842424
Informations de copyright
© 2020, Siems et al.
Déclaration de conflit d'intérêts
SS, OJ, ME, NK, LW, DS, KK, DH, RJ, RF, MS, MR, PB, HW No competing interests declared
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