Histological and magnified endoscopic evaluation of villous atrophy in gastrointestinal graft-versus-host disease.
Adolescent
Adult
Aged
Allografts
Atrophy
Duodenal Diseases
/ pathology
Duodenum
/ pathology
Endoscopy, Gastrointestinal
Female
Graft vs Host Disease
/ pathology
Hematopoietic Stem Cell Transplantation
Humans
Ileal Diseases
/ pathology
Ileum
/ pathology
Intestinal Mucosa
/ pathology
Male
Middle Aged
Retrospective Studies
Graft-versus-host disease
Hematopoietic stem cell transplantation
Magnified endoscopy
Villous atrophy
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
01
10
2019
accepted:
15
02
2020
pubmed:
5
3
2020
medline:
13
5
2020
entrez:
5
3
2020
Statut:
ppublish
Résumé
To measure histological villous atrophy and to clarify the diagnostic accuracy of endoscopic villous atrophy in gastrointestinal graft-versus-host disease. Data for patients who underwent upper and/or lower endoscopic examinations after hematopoietic stem cell transplantation were retrospectively collected. In study 1, group A included 56 patients in whom GI-GVHD was histologically confirmed and group B included 60 patients in whom GI-GVHD was not histologically confirmed. Group C included 59 patients before HSCT. The lengths of villi and crypts in the duodenum and terminal ileum were histologically measured. In study 2, the diagnostic accuracies of villous atrophy of the duodenum and of the terminal ileum using magnifying endoscopy were evaluated. In study 1, the lengths of villi and the villi/crypt (V/C) ratios of the duodenum and terminal ileum in group A were significantly smaller than those in the other groups (p < 0.05). V/C ratio was moderately correlated with clinical severity, histological grades, and endoscopic grades in the terminal ileum. In study 2, the diagnostic accuracies of magnified images for villous atrophy were 83.8% in the duodenum and 94.9% in the terminal ileum. Magnifying endoscopy enables evaluation of villous atrophy and is useful for optical biopsy of GVHD.
Identifiants
pubmed: 32130472
doi: 10.1007/s00277-020-03966-y
pii: 10.1007/s00277-020-03966-y
doi:
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1121-1128Références
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