Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar.
atherosclerosis
endothelial dysfunction
geroscience
microcirculation
senescence
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
received:
08
10
2019
revised:
15
11
2019
accepted:
19
11
2019
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macrovascular and microvascular diseases associated with old age. The role of cellular senescence in development of vascular aging phenotypes is highlighted, and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. The evidence supporting a role for interorgan communication and circulating progeronic and antigeronic factors in vascular aging is discussed.
Identifiants
pubmed: 32130929
pii: S0735-1097(20)30068-1
doi: 10.1016/j.jacc.2019.11.061
pmc: PMC8559983
mid: NIHMS1569132
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
931-941Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM125528
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052363
Pays : United States
Informations de copyright
Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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