Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer.
BCL-2
BCL-xL
MCL-1
apoptosis
cancer therapeutics
targeted therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
02 Mar 2020
02 Mar 2020
Historique:
received:
01
02
2020
revised:
23
02
2020
accepted:
27
02
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
7
3
2020
Statut:
epublish
Résumé
Deregulated cellular apoptosis is a hallmark of cancer and chemotherapy resistance. The B-cell lymphoma 2 (BCL-2) protein family members are sentinel molecules that regulate the mitochondrial apoptosis machinery and arbitrate cell fate through a delicate balance between pro- and anti-apoptotic factors. The recognition of the anti-apoptotic
Identifiants
pubmed: 32131385
pii: cancers12030574
doi: 10.3390/cancers12030574
pmc: PMC7139457
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Medical Research Council
ID : MOH-FLWSHP19may-0006
Organisme : National Medical Research Council
ID : NMRC/TA17nov003
Organisme : National Medical Research Council
ID : NMRC/CSA-SI/0006/2016
Organisme : National Medical Research Council
ID : NMRC CIRG/1433/2015
Organisme : National Medical Research Council
ID : OFIRG/0041/2017
Références
Leuk Lymphoma. 2013 May;54(5):1097-100
pubmed: 22866921
Cancer Res. 2008 May 1;68(9):3413-20
pubmed: 18451169
Mol Cancer Ther. 2005 Jan;4(1):13-21
pubmed: 15657349
Oncogene. 2008 Dec;27 Suppl 1:S149-57
pubmed: 19641500
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9
pubmed: 16166262
Nat Chem Biol. 2012 Jul;8(7):639-45
pubmed: 22634637
Nature. 2005 Jun 2;435(7042):677-81
pubmed: 15902208
Nat Med. 2015 Feb;21(2):178-84
pubmed: 25599133
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3850-5
pubmed: 10725400
J Clin Invest. 2016 Oct 3;126(10):3827-3836
pubmed: 27599292
Cell Death Differ. 2018 Jan;25(1):13-20
pubmed: 29099481
PLoS One. 2014 Jan 13;9(1):e80836
pubmed: 24454684
Leukemia. 2014 Aug;28(8):1657-65
pubmed: 24451410
Nature. 2016 Oct 27;538(7626):477-482
pubmed: 27760111
Blood. 2017 Nov 30;130(22):2392-2400
pubmed: 28847998
Nat Cell Biol. 2015 Oct;17(10):1270-81
pubmed: 26344567
Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):534-9
pubmed: 25052051
Cell Death Dis. 2014 Mar 06;5:e1098
pubmed: 24603326
Br J Cancer. 2001 Nov 2;85(9):1359-67
pubmed: 11720475
Science. 2001 Apr 27;292(5517):727-30
pubmed: 11326099
Blood. 2011 Dec 8;118(24):6380-6
pubmed: 21998213
ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93
pubmed: 25313317
Cancer Res. 2013 Dec 1;73(23):6998-7008
pubmed: 24097825
Nat Med. 2013 Feb;19(2):202-8
pubmed: 23291630
Cancer Cell. 2006 Nov;10(5):389-99
pubmed: 17097561
N Engl J Med. 2018 Mar 22;378(12):1107-1120
pubmed: 29562156
Sci Rep. 2017 Dec 21;7(1):18007
pubmed: 29269870
Cancer Chemother Pharmacol. 2014 Feb;73(2):363-71
pubmed: 24297683
Cancer Cell. 2013 Jul 8;24(1):120-9
pubmed: 23845444
Cells. 2019 Sep 29;8(10):
pubmed: 31569576
Oncol Lett. 2018 Jan;15(1):901-907
pubmed: 29422965
Blood. 2017 Nov 30;130(22):2401-2409
pubmed: 29018077
Cell Death Differ. 2006 Aug;13(8):1419-21
pubmed: 16645636
N Engl J Med. 2018 Mar 29;378(13):1211-1223
pubmed: 29590547
Oncotarget. 2015 Feb 20;6(5):2667-79
pubmed: 25596730
Leuk Lymphoma. 2014 Dec;55(12):2932-4
pubmed: 24611663
Blood. 2012 Mar 1;119(9):2171-2
pubmed: 22383790
Nat Med. 2013 Feb;19(2):131-3
pubmed: 23389605
Cancer Res. 2005 Jul 15;65(14):6282-93
pubmed: 16024630
Blood. 2011 Jun 9;117(23):6214-26
pubmed: 21474673
Clin Cancer Res. 2012 Jun 1;18(11):3163-9
pubmed: 22496272
Blood. 2016 Jun 23;127(25):3215-24
pubmed: 27069256
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1578-83
pubmed: 10677502
J Clin Oncol. 2005 May 20;23(15):3404-11
pubmed: 15824414
Cell Death Dis. 2010 May 06;1:e40
pubmed: 21364647
Oncotarget. 2015 Nov 3;6(34):36113-25
pubmed: 26416351
EMBO J. 1998 Feb 16;17(4):1029-39
pubmed: 9463381
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
Nanomedicine. 2018 Apr 8;14(4):1301-1313
pubmed: 29641982
Blood. 2008 Nov 1;112(9):3807-17
pubmed: 18599795
Cell. 2014 Dec 4;159(6):1263-76
pubmed: 25480292
PLoS One. 2019 May 31;14(5):e0217657
pubmed: 31150457
Blood. 2016 Jan 21;127(3):279-86
pubmed: 26576865
Oncogene. 2007 Apr 5;26(16):2374-80
pubmed: 17016430
Neoplasma. 2009;56(5):404-13
pubmed: 19580342
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7
pubmed: 18040043
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3516-20
pubmed: 7682708
Blood Adv. 2021 Oct 12;5(19):3748-3759
pubmed: 34470049
Leuk Lymphoma. 2007 Nov;48(11):2204-12
pubmed: 17926190
Clin Cancer Res. 2017 Aug 15;23(16):4527-4533
pubmed: 28100580
PLoS One. 2014 Oct 06;9(10):e108694
pubmed: 25285531
J Thorac Oncol. 2011 Oct;6(10):1757-60
pubmed: 21918390
J Hematol Oncol. 2016 Jun 28;9(1):50
pubmed: 27353420
Nat Rev Mol Cell Biol. 2013 Sep;14(9):546
pubmed: 23900393
J Clin Oncol. 2012 Mar 20;30(9):980-8
pubmed: 22331940
Nat Rev Mol Cell Biol. 2011 Jun 23;12(7):439-52
pubmed: 21697901
Blood. 2018 Oct 11;132(15):1568-1572
pubmed: 30111609
Cell Death Differ. 2018 Jan;25(1):65-80
pubmed: 29149100
Trends Pharmacol Sci. 2008 Jun;29(6):302-13
pubmed: 18423896
Cell. 1997 Oct 17;91(2):231-41
pubmed: 9346240
J Clin Oncol. 2019 May 20;37(15):1277-1284
pubmed: 30892988
Leukemia. 2011 Apr;25(4):638-47
pubmed: 21358717
Nat Med. 2012 Mar 18;18(4):521-8
pubmed: 22426421
Leukemia. 2016 Mar;30(3):761-4
pubmed: 26174630
Immunol Lett. 2013 Sep-Oct;155(1-2):36-9
pubmed: 24095849
Blood. 2007 Jun 15;109(12):5430-8
pubmed: 17332241
Int J Mol Sci. 2018 Jan 20;19(1):
pubmed: 29361709
Blood. 2002 Mar 15;99(6):1885-93
pubmed: 11877256
Antioxid Redox Signal. 2010 Sep 15;13(6):807-19
pubmed: 20367277
Cell Death Differ. 2015 Dec;22(12):2098-106
pubmed: 26045046
Cancer Discov. 2016 Oct;6(10):1106-1117
pubmed: 27520294
Cell Death Differ. 2015 Jul;22(7):1071-80
pubmed: 25952548
EMBO J. 2019 Jun 3;38(11):
pubmed: 30979778
Nat Commun. 2019 Nov 14;10(1):5167
pubmed: 31727888
Blood Adv. 2017 Jun 13;1(14):933-946
pubmed: 29034364
Nat Commun. 2019 Apr 11;10(1):1679
pubmed: 30976011
Genes Dev. 2012 Jan 15;26(2):120-5
pubmed: 22279045
Cell Death Dis. 2015 Jan 15;6:e1593
pubmed: 25590803
J Clin Oncol. 2018 Jul 1;36(19):1973-1980
pubmed: 29715056
Front Oncol. 2019 Jan 07;8:645
pubmed: 30666297
Oncogene. 2004 Apr 12;23(16):2861-74
pubmed: 15077149
N Engl J Med. 2019 Jun 06;380(23):2225-2236
pubmed: 31166681
Haematologica. 2015 Aug;100(8):e302-6
pubmed: 25957396
Biochem Soc Trans. 2012 Feb;40(1):73-8
pubmed: 22260668
Oncogene. 2008 Dec;27 Suppl 1:S41-52
pubmed: 19641506
J Clin Oncol. 2017 Mar 10;35(8):826-833
pubmed: 28095146
Biochim Biophys Acta Biomembr. 2017 Jan;1859(1):17-27
pubmed: 27755971
Clin Cancer Res. 2015 Aug 15;21(16):3705-15
pubmed: 25829398
Leukemia. 2014 Mar;28(3):554-65
pubmed: 24280866
Oncogene. 2005 Feb 17;24(8):1348-58
pubmed: 15608680
Blood. 2013 Apr 4;121(14):2689-703
pubmed: 23393050
Brief Funct Genomic Proteomic. 2008 Jan;7(1):27-34
pubmed: 18283052
Nature. 2010 Feb 18;463(7283):899-905
pubmed: 20164920
Cancer Cell. 2006 May;9(5):351-65
pubmed: 16697956
Clin Cancer Res. 2009 May 1;15(9):3172-6
pubmed: 19366825
Br J Cancer. 2007 Feb 26;96(4):600-8
pubmed: 17311012
Oncogene. 2015 Jul;34(28):3617-26
pubmed: 25263438
Mol Cell. 2008 May 9;30(3):369-80
pubmed: 18471982
Leuk Lymphoma. 2015;56(12):3336-42
pubmed: 25971907
Blood. 2010 Apr 22;115(16):3304-13
pubmed: 20197552
Annu Rev Physiol. 2008;70:73-91
pubmed: 17680735
FASEB J. 2006 Oct;20(12):2147-9
pubmed: 16935937
PLoS One. 2012;7(10):e47060
pubmed: 23056582
Leuk Lymphoma. 2014 Dec;55(12):2761-8
pubmed: 24679008
Blood. 2019 Jan 3;133(1):7-17
pubmed: 30361262
Onco Targets Ther. 2011;4:169-83
pubmed: 22162923
Nat Rev Cancer. 2013 Jul;13(7):455-65
pubmed: 23783119
Leukemia. 2013 Jun;27(6):1381-90
pubmed: 23257783
Mol Cancer Ther. 2016 May;15(5):1132-44
pubmed: 26939706
Nat Commun. 2018 Dec 17;9(1):5341
pubmed: 30559424
Exp Hematol. 2008 May;36(5):568-76
pubmed: 18346839
J Clin Oncol. 2007 Mar 20;25(9):1114-20
pubmed: 17296974
Nat Med. 2016 Mar;22(3):262-9
pubmed: 26828195
Semin Cancer Biol. 2015 Dec;35 Suppl:S78-S103
pubmed: 25936818
J Cancer Res Clin Oncol. 2016 Sep;142(9):2013-22
pubmed: 27043233
Sci Transl Med. 2015 Mar 18;7(279):279ra40
pubmed: 25787766
Leukemia. 2016 May;30(5):1086-93
pubmed: 26707935
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2766-71
pubmed: 21768359
Cancer Res. 2015 Apr 1;75(7):1366-75
pubmed: 25649768
Sci Transl Med. 2016 Sep 7;8(355):355ra117
pubmed: 27605552
Drug Resist Updat. 2012 Feb-Apr;15(1-2):70-80
pubmed: 22325423
J Cell Biochem. 2014 Apr;115(4):632-40
pubmed: 24453042
J Clin Oncol. 2012 Feb 10;30(5):488-96
pubmed: 22184378
Blood. 2009 Jan 8;113(2):299-305
pubmed: 18931344
Mol Cancer Ther. 2008 Oct;7(10):3265-74
pubmed: 18852130
Blood. 2014 Oct 2;124(14):2223-34
pubmed: 25082878
Blood. 2018 Sep 20;132(12):1248-1264
pubmed: 30012635
Lancet Oncol. 2017 Feb;18(2):230-240
pubmed: 28089635
Oncotarget. 2016 Jul 5;7(27):42374-42384
pubmed: 27283896
Br J Haematol. 2017 Aug;178(3):364-379
pubmed: 28449207
Int J Cancer. 2002 Apr 1;98(4):498-504
pubmed: 11920608
Cell Death Differ. 2010 Mar;17(3):408-20
pubmed: 19834492
Cell Death Differ. 2008 May;15(5):820-30
pubmed: 18309326
J Clin Oncol. 2019 Feb 1;37(4):269-277
pubmed: 30523712
Ann Oncol. 2012 Jul;23(7):1803-8
pubmed: 22112969
Nat Rev Drug Discov. 2008 Dec;7(12):989-1000
pubmed: 19043450
Clin Exp Pharmacol Physiol. 2016 Aug;43(8):723-37
pubmed: 27097837
Cell Death Dis. 2014 Sep 18;5:e1423
pubmed: 25232677
Oncotarget. 2016 May 10;7(19):27753-63
pubmed: 27049723
Blood Rev. 2018 Jan;32(1):8-28
pubmed: 28802908
Cancer Res. 2012 Jun 15;72(12):3069-79
pubmed: 22525702
J Thorac Oncol. 2011 Apr;6(4):781-5
pubmed: 21289522
J Biol Chem. 1997 May 2;272(18):11671-3
pubmed: 9115213
Int J Cancer. 2009 Feb 1;124(3):511-5
pubmed: 19003982
Cold Spring Harb Perspect Biol. 2015 Dec 01;7(12):
pubmed: 26626938