Current Role of Intraoperative Frozen Section Examination of Sentinel Lymph Node in Early Breast Cancer.

Breast Neoplasms / pathology Female Frozen Sections / methods Humans Retrospective Studies Sentinel Lymph Node / pathology Sentinel Lymph Node Biopsy / methods
Breast cancer intraoperative frozen section sentinel lymph node

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 14 01 2020
revised: 02 02 2020
accepted: 04 02 2020
entrez: 6 3 2020
pubmed: 7 3 2020
medline: 16 4 2020
Statut: ppublish

Résumé

The aim of this study was to evaluate the current role of frozen section in identifying patients who could benefit from an immediate axillary lymph node dissection (ALND), following the criteria of the ASOCOG Z0011 and IBCSG 23-10 trials. A retrospective review was performed involving 2,079 patients with early breast cancer who underwent conservative surgery or total mastectomy with sentinel lymph node biopsy. Sensitivity and diagnostic accuracy were 63.8% and 90.3%, respectively. Sensitivity was significantly higher (p<0.001) in finding macrometastases (81.8%) compared to micrometastases (11.9%). Frozen section was useful only in 7.7% of the patients who met the criteria of the IBCSG 23-01 and ACOSOG Z0011 trials. Frozen section continues to be very useful in the intraoperative assessment of the SLN, offering a high sensitivity and diagnostic accuracy. Omission of ALND in 24.4% of patients who met the ACOSOG Z0011 criteria would have resulted in their undertreatment.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
The aim of this study was to evaluate the current role of frozen section in identifying patients who could benefit from an immediate axillary lymph node dissection (ALND), following the criteria of the ASOCOG Z0011 and IBCSG 23-10 trials.
PATIENTS AND METHODS METHODS
A retrospective review was performed involving 2,079 patients with early breast cancer who underwent conservative surgery or total mastectomy with sentinel lymph node biopsy.
RESULTS RESULTS
Sensitivity and diagnostic accuracy were 63.8% and 90.3%, respectively. Sensitivity was significantly higher (p<0.001) in finding macrometastases (81.8%) compared to micrometastases (11.9%). Frozen section was useful only in 7.7% of the patients who met the criteria of the IBCSG 23-01 and ACOSOG Z0011 trials.
CONCLUSION CONCLUSIONS
Frozen section continues to be very useful in the intraoperative assessment of the SLN, offering a high sensitivity and diagnostic accuracy. Omission of ALND in 24.4% of patients who met the ACOSOG Z0011 criteria would have resulted in their undertreatment.

Identifiants

DOI: 10.21873/anticanres.14124 PMID: 32132079
pubmed: 32132079
pii: 40/3/1711
doi: 10.21873/anticanres.14124
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1711-1717

Informations de copyright

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Calogero Cipolla (C)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Palermo, Italy calogero.cipolla@unipa.it.
ORCID: 0000-0003-4396-3563

Giuseppa Graceffa (G)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Daniela Cabibi (D)

Department of Sciences for the Promotion of Health and Mother and Child Care, University of Palermo, Palermo, Italy.

Giuseppe Gangi (G)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Mario Latteri (M)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Maria Rosaria Valerio (MR)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Salvatore Vieni (S)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Current Role of Intraoperative Frozen Section...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques histologiques › Techniques de préparation histocytologique › Microtomie › Cryo-ultramicrotomie › Coupes minces congelées › Current Role of Intraoperative Frozen Section...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Current Role of Intraoperative Frozen Section...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Current Role of Intraoperative Frozen Section...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Noeud lymphatique sentinelle › Current Role of Intraoperative Frozen Section...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Biopsie de noeud lymphatique sentinelle › Current Role of Intraoperative Frozen Section...