Participant-Centered Strategies for Overcoming Barriers to Biospecimen Collection among Spanish-Speaking Latina Breast Cancer Survivors.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ genetics
Breast Neoplasms
/ diagnosis
California
Cancer Survivors
/ psychology
Community-Based Participatory Research
Culturally Competent Care
/ methods
DNA
/ genetics
Feasibility Studies
Female
Follow-Up Studies
Hair
/ chemistry
Hispanic or Latino
/ psychology
Humans
Middle Aged
Minority Groups
/ psychology
Patient Participation
/ psychology
Patient-Centered Care
/ methods
Program Evaluation
Saliva
/ chemistry
Specimen Handling
/ psychology
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
09
08
2019
revised:
12
11
2019
accepted:
07
01
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
27
4
2021
Statut:
ppublish
Résumé
Latinos are underrepresented in biomedical research, particularly biomarker research, yet they constitute the nation's largest ethnic/racial minority. Optimal methods for obtaining biospecimens for biomarker research among Latinos need to be identified. To minimize barriers and enhance participation, this study developed and tested tailored strategies for collecting biomarkers of chronic stress and premature aging among Spanish-speaking Latina breast cancer survivors. This study used a community-based participatory approach and selected hair and saliva as noninvasive biospecimens to assess telomere length, the cortisol awakening response (CAR), and hair cortisol concentration. We developed bilingual multimedia instructional materials, and community health workers assisted in collections. Telephone surveys assessed willingness to participate in future studies, barriers to sample collection, and recommendations for improving the strategies. A total of 103 participants were recruited over 18 months from two rural sites in California, and 88 were retained at 6-month follow-up. At baseline, rates of donating salivary DNA for telomere length measurement, saliva for CAR analysis, and hair for cortisol concentration were 98%, 89%, and 52%, respectively. At follow-up, rates were 83%, 76%, and 55%, respectively. The majority of participants reported being very willing to provide hair (72%) or saliva (74%) for future studies. Our results support the feasibility of including minorities in biomedical research. We report excellent rates of saliva collection when community partners are engaged in the process, and when patient-centered and culturally tailored recruitment methods are implemented. The development of methods to facilitate the inclusion of minorities in biomedical research is critical to eliminate racial/ethnic health disparities.
Sections du résumé
BACKGROUND
Latinos are underrepresented in biomedical research, particularly biomarker research, yet they constitute the nation's largest ethnic/racial minority. Optimal methods for obtaining biospecimens for biomarker research among Latinos need to be identified. To minimize barriers and enhance participation, this study developed and tested tailored strategies for collecting biomarkers of chronic stress and premature aging among Spanish-speaking Latina breast cancer survivors.
METHODS
This study used a community-based participatory approach and selected hair and saliva as noninvasive biospecimens to assess telomere length, the cortisol awakening response (CAR), and hair cortisol concentration. We developed bilingual multimedia instructional materials, and community health workers assisted in collections. Telephone surveys assessed willingness to participate in future studies, barriers to sample collection, and recommendations for improving the strategies.
RESULTS
A total of 103 participants were recruited over 18 months from two rural sites in California, and 88 were retained at 6-month follow-up. At baseline, rates of donating salivary DNA for telomere length measurement, saliva for CAR analysis, and hair for cortisol concentration were 98%, 89%, and 52%, respectively. At follow-up, rates were 83%, 76%, and 55%, respectively. The majority of participants reported being very willing to provide hair (72%) or saliva (74%) for future studies.
CONCLUSIONS
Our results support the feasibility of including minorities in biomedical research. We report excellent rates of saliva collection when community partners are engaged in the process, and when patient-centered and culturally tailored recruitment methods are implemented.
IMPACT
The development of methods to facilitate the inclusion of minorities in biomedical research is critical to eliminate racial/ethnic health disparities.
Identifiants
pubmed: 32132128
pii: 29/3/606
doi: 10.1158/1055-9965.EPI-19-0942
pmc: PMC7062229
mid: NIHMS1549812
doi:
Substances chimiques
Biomarkers, Tumor
0
DNA
9007-49-2
Banques de données
ClinicalTrials.gov
['NCT02931552']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
606-615Subventions
Organisme : NIA NIH HHS
ID : P30 AG015272
Pays : United States
Organisme : NIGMS NIH HHS
ID : RL5 GM118984
Pays : United States
Organisme : NIGMS NIH HHS
ID : UL1 GM118985
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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