Direct Determination of Pyrazinamide (PZA) Susceptibility by Sputum Microscopic Observation Drug Susceptibility (MODS) Culture at Neutral pH: the MODS-PZA Assay.

Amidohydrolases / genetics Antitubercular Agents / pharmacology Humans Hydrogen-Ion Concentration Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Pharmaceutical Preparations Pyrazinamide / pharmacology Sputum Tuberculosis, Multidrug-Resistant / drug therapy
MODS drug susceptibility pyrazinamide sputum tuberculosis

Journal

Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564

Informations de publication

Date de publication:
23 04 2020
Historique:
received: 16 07 2019
accepted: 27 02 2020
pubmed: 7 3 2020
medline: 24 6 2021
entrez: 6 3 2020
Statut: epublish

Résumé

Pyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens due to its particular action on the persistent forms of

Identifiants

DOI: 10.1128/JCM.01165-19 PMID: 32132191 PMC: PMC7180241
pubmed: 32132191
pii: JCM.01165-19
doi: 10.1128/JCM.01165-19
pmc: PMC7180241
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Pharmaceutical Preparations 0
Pyrazinamide 2KNI5N06TI
Amidohydrolases EC 3.5.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P019978/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P019978/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 099805/Z/112/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Alcántara et al.

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Auteurs

Roberto Alcántara (R)

Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú roberto.alcantara@alumni-upch.edu.pe patricia.sheen@upch.pe.

Patricia Fuentes (P)

Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.

Lisette Marin (L)

Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.

Daniela E Kirwan (DE)

Infection and Immunity Research Institute, St George's, University of London, London, United Kingdom.

Robert H Gilman (RH)

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Mirko Zimic (M)

Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.

Patricia Sheen (P)

Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú roberto.alcantara@alumni-upch.edu.pe patricia.sheen@upch.pe.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Préparations pharmaceutiques › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrazines › Pyrazinamide › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Expectoration › Direct Determination of Pyrazinamide (PZA)...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Tuberculose multirésistante › Direct Determination of Pyrazinamide (PZA)...