Tibial subchondral trabecular bone micromechanical and microarchitectural properties are affected by alignment and osteoarthritis stage.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
received:
25
07
2019
accepted:
04
12
2019
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
27
11
2020
Statut:
epublish
Résumé
At advanced knee osteoarthritis (OA) stages subchondral trabecular bone (STB) is altered. Lower limb alignment plays a role in OA progression and modify the macroscopic loading of the medial and lateral condyles of the tibial plateau. How the properties of the STB relate to alignment and OA stage is not well defined. OA stage (KL scores 2-4) and alignment (HKA from 17° Varus to 8° Valgus) of 30 patients were measured and their tibial plateau were collected after total knee arthroplasty. STB tissue elastic modulus, bone volume fraction (BV/TV) and trabecula thickness (Tb.Th) were evaluated with nanoindentation and µCT scans (8.1 µm voxel-size) of medial and lateral samples of each plateau. HKA and KL scores were statistically significantly associated with STB elastic modulus, BV/TV and Tb.Th. Medial to lateral BV/TV ratio correlated with HKA angle (R = -0.53, p = 0.016), revealing a higher ratio for varus than valgus subjects. STB properties showed lower values for KL stage 4 patients. Tissue elastic modulus ratios and BV.TV ratios were strongly correlated (R = 0.81, p < 0.001). Results showed that both micromechanical and microarchitectural properties of STB are affected by macroscopic loading at late stage knee OA. For the first time, a strong association between tissue stiffness and quantity of OA STB was demonstrated.
Identifiants
pubmed: 32132556
doi: 10.1038/s41598-020-60464-x
pii: 10.1038/s41598-020-60464-x
pmc: PMC7055326
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3975Références
Sharma, L. et al. The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis. Jama 286, 188 (2001).
pubmed: 11448282
doi: 10.1001/jama.286.2.188
Brouwer, G. M. et al. Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum. 56, 1204–1211 (2007).
pubmed: 17393449
doi: 10.1002/art.22515
pmcid: 17393449
Miyazaki, T., Wada, M. & Kawahara, H. Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis. Ann. Rheum. Dis. 61, 617–622 (2002).
pubmed: 12079903
pmcid: 1754164
doi: 10.1136/ard.61.7.617
Wada, M. et al. Relationships among bone mineral densities, static alignment and dynamic load in patients with medial compartment knee osteoarthritis. Rheumatology 40, 499–505 (2001).
pubmed: 11371657
doi: 10.1093/rheumatology/40.5.499
pmcid: 11371657
Hurwitz, D. E., Ryals, A. R., Karar, A., Case, J. P. & Andriacchi, T. P. Static Alignment is a Better Indicator of the Dynamic Knee Joint Loads During Gait in Subjects with Knee Osteoarthritis Than Radiographic Disease Severity, Toe Out Angle and Pain. Orthop. Res. Soc. 20, 101–107 (2002).
doi: 10.1016/S0736-0266(01)00081-X
Rivière, C. et al. Alignment options for total knee arthroplasty: A systematic review. Orthop. Traumatol. Surg. Res. 103, 1047–1056 (2017).
pubmed: 28864235
doi: 10.1016/j.otsr.2017.07.010
pmcid: 28864235
Burr, D. B. & Gallant, M. A. Bone remodelling in osteoarthritis. Nature Reviews Rheumatology, https://doi.org/10.1038/nrrheum.2012.130 (2012).
pubmed: 22868925
doi: 10.1038/nrrheum.2012.130
pmcid: 22868925
Hunter, D. J. et al. Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized. Arthritis Res. Ther. 11, 1–9 (2009).
doi: 10.1186/ar2601
Kazakia, G. J. et al. Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees. Osteoarthr. Cartil. 21, 94–101 (2013).
pubmed: 23025926
doi: 10.1016/j.joca.2012.09.008
pmcid: 23025926
Tanamas, S. K. et al. Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: A longitudinal study. Rheumatology 49, 2413–2419 (2010).
pubmed: 20823092
doi: 10.1093/rheumatology/keq286
pmcid: 20823092
Crema, M. D. et al. Subchondral Cystlike Lesions Develop Longitudinally in Areas of Bone Marrow Edema–like Lesions in Patients with or at Risk for Knee Osteoarthritis: Detection with MR Imaging—The MOST Study. Radiology 256, 855–862 (2010).
pubmed: 20530753
pmcid: 2923728
doi: 10.1148/radiol.10091467
Roberts, B. C. et al. Systematic mapping of the subchondral bone 3D microarchitecture in the human tibial plateau: Variations with joint alignment. J. Orthop. Res. 35, 1927–1941 (2017).
pubmed: 27891668
doi: 10.1002/jor.23474
pmcid: 27891668
Finnilä, M. A. J. et al. Association between subchondral bone structure and osteoarthritis histopathological grade. J. Orthop. Res. 35, 785–792 (2017).
pubmed: 27227565
doi: 10.1002/jor.23312
pmcid: 27227565
Cox, L. G. E., van Donkelaar, C. C., van Rietbergen, B., Emans, P. J. & Ito, K. Decreased bone tissue mineralization can partly explain subchondral sclerosis observed in osteoarthritis. Bone 50, 1152–1161 (2012).
pubmed: 22342798
doi: 10.1016/j.bone.2012.01.024
Patel, V. et al. MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens. J. Orthropedic Res. 21, 6–13 (2003).
doi: 10.1016/S0736-0266(02)00093-1
Ding, M., Odgaard, A. & Hvid, I. Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis. J. Bone Joint Surg. Br. 85-B, 906–912 (2003).
doi: 10.1302/0301-620X.85B6.12595
Roberts, B. C. et al. Relationships between in vivo dynamic knee joint loading, static alignment and tibial subchondral bone microarchitecture in end-stage knee osteoarthritis. Osteoarthr. Cartil. 26, 547–556 (2018).
pubmed: 29382604
doi: 10.1016/j.joca.2018.01.014
Zysset, P. I., Sonny, M. & Hayes, W. C. Morphology-mechanical Property Relations in Trabecular Bone of the Osteoarthritic proximal Tibia. J. Arthroplasty 9, 203–216 (1994).
pubmed: 8014652
doi: 10.1016/0883-5403(94)90070-1
pmcid: 8014652
Li, B. & Aspden, R. M. Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J. Bone Miner. Res. 12, 641–51 (1997).
pubmed: 9101376
doi: 10.1359/jbmr.1997.12.4.641
pmcid: 9101376
Day, J. S. et al. A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J. Orthop. Res. 19, 914–918 (2001).
pubmed: 11562141
doi: 10.1016/S0736-0266(01)00012-2
pmcid: 11562141
Ding, M., Danielsen, C. C. & Hvid, I. Bone density does not reflect mechanical properties in early-stage arthrosis. Acta Orthop. Scand. 72, 181–185 (2001).
pubmed: 11372950
doi: 10.1080/000164701317323444
pmcid: 11372950
Mansell, J. P. & Bailey, A. J. Abnormal cancellous bone collagen metabolism in osteoarthritis. J. Clin. Invest. 101, 1596–1603 (1998).
pubmed: 9541489
pmcid: 508740
doi: 10.1172/JCI867
Bailey, A. J., Mansell, J. P., Sims, T. J. & Banse, X. Biochemical and mechanical properties of subchondral bone in osteoarthritis. Biorheology 41, 349–358 (2004).
pubmed: 15299267
pmcid: 15299267
Dall’Ara, E., Öhman, C., Baleani, M. & Viceconti, M. Reduced tissue hardness of trabecular bone is associated with severe osteoarthritis. J. Biomech. 44, 1593–1598 (2011).
pubmed: 21496822
doi: 10.1016/j.jbiomech.2010.12.022
pmcid: 21496822
Coats, A. M., Zioupos, P. & Aspden, R. M. Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis. Calcif. Tissue Int. 73, 66–71 (2003).
pubmed: 14506956
doi: 10.1007/s00223-002-2080-8
pmcid: 14506956
Gustafson, M. B. et al. Calcium buffering is required to maintain bone stiffness in saline solution. J. Biomech. 29, 1191–1194 (1996).
pubmed: 8872276
doi: 10.1016/0021-9290(96)00020-6
pmcid: 8872276
Tawy, G. F., Rowe, P. J. & Riches, P. E. Thermal Damage Done to Bone by Burring and Sawing With and Without Irrigation in Knee Arthroplasty. J. Arthroplasty 31, 1102–1108 (2016).
pubmed: 26718777
doi: 10.1016/j.arth.2015.11.002
pmcid: 26718777
Oliver, C. & Pharr, M. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. Journal of Materials Research 7, 1564–1583 (1992).
doi: 10.1557/JMR.1992.1564
Rodriguez-Florez, N., Oyen, M. L. & Shefelbine, S. J. Insight into differences in nanoindentation properties of bone. J. Mech. Behav. Biomed. Mater. 18, 90–99 (2013).
pubmed: 23262307
doi: 10.1016/j.jmbbm.2012.11.005
pmcid: 23262307
Peters, A. E., Akhtar, R., Comerford, E. J. & Bates, K. T. The effect of ageing and osteoarthritis on the mechanical properties of cartilage and bone in the human knee joint. Sci. Rep. 8, 5931 (2018).
pubmed: 29651151
pmcid: 5897376
doi: 10.1038/s41598-018-24258-6
Cai, X. et al. Cortical bone elasticity measured by resonant ultrasound spectroscopy is not altered by defatting and synchrotron X-ray imaging. J. Mech. Behav. Biomed. Mater. 72, 241–245 (2017).
pubmed: 28501721
doi: 10.1016/j.jmbbm.2017.05.012
pmcid: 28501721
Reina, N. et al. BMI-related microstructural changes in the tibial subchondral trabecular bone of patients with knee osteoarthritis. J. Orthop. Res. 35, 1653–1660 (2017).
pubmed: 27747928
doi: 10.1002/jor.23459
Zuo, Q. et al. Characterization of nano-structural and nano-mechanical properties of osteoarthritic subchondral bone. BMC Musculoskelet. Disord. 17, 1–13 (2016).
doi: 10.1186/s12891-016-1226-1
Wolfram, U., Wilke, H. J. & Zysset, P. K. Rehydration of vertebral trabecular bone: Influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral level. Bone 46, 348–354 (2010).
pubmed: 19818423
doi: 10.1016/j.bone.2009.09.035
Tomanik, M., Nikodem, A. & Filipiak, J. Microhardness of human cancellous bone tissue in progressive hip osteoarthritis. J. Mech. Behav. Biomed. Mater. 64, 86–93 (2016).
pubmed: 27484953
doi: 10.1016/j.jmbbm.2016.07.022
Paley, D. Principles of Deformity Correction., https://doi.org/10.1007/978-3-642-59373-4 (Springer Berlin Heidelberg, 2002).
doi: 10.1007/978-3-642-59373-4
Bellemans, J., Colyn, W., Vandenneucker, H. & Victor, J. The Chitranjan Ranawat Award: Is Neutral Mechanical Alignment Normal for All Patients?: The Concept of Constitutional Varus. Clin. Orthop. Relat. Res. 470, 45–53 (2011).
pmcid: 3237976
doi: 10.1007/s11999-011-1936-5
Chen, Y. et al. Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis. J. Bone Miner. Res. 33, 316–327 (2018).
pubmed: 29044705
doi: 10.1002/jbmr.3313
pmcid: 29044705
Kim, G., Cole, J. H., Boskey, A. L., Baker, S. P. & Van Der Meulen, M. C. H. Reduced tissue-level stiffness and mineralization in osteoporotic cancellous bone. Calcif. Tissue Int. 95, 125–131 (2014).
pubmed: 24888692
pmcid: 4104238
doi: 10.1007/s00223-014-9873-4
Wolfram, U., Wilke, H. J. & Zysset, P. K. Valid µ finite element models of vertebral trabecular bone can be obtained using tissue properties measured with nanoindentation under wet conditions. J. Biomech. 43, 1731–1737 (2010).
pubmed: 20206932
doi: 10.1016/j.jbiomech.2010.02.026
pmcid: 20206932
Pijls, B. G., Plevier, J. W. M. & Nelissen, R. G. H. H. RSA migration of total knee replacements. Acta Orthop. 3674, 1–9 (2018).