A competent bidrug loaded water soluble chitosan derivative for the effective inhibition of breast cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
received:
28
06
2019
accepted:
13
02
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
27
11
2020
Statut:
epublish
Résumé
Drug resistance and damage caused to the normal cells are the drawbacks which have limited the use of the existing effective anticancer drugs. Attainment of a steady and extended release by encapsulating dual drugs into biocompatible and biodegradable vehicles is the key to enable the use of these drugs for effective inhibition of cancer. In this study, carboxymethyl chitosan (CMCS), a proficient water-soluble derivative of chitosan has been synthesized using chemical route and used for the delivery of 5-Fluorouracil and doxorubicin individually as well as in combination. Carboxymethylation occuring at -NH
Identifiants
pubmed: 32132583
doi: 10.1038/s41598-020-60888-5
pii: 10.1038/s41598-020-60888-5
pmc: PMC7055325
doi:
Substances chimiques
Drug Carriers
0
carboxymethyl-chitosan
0
Water
059QF0KO0R
Doxorubicin
80168379AG
Chitosan
9012-76-4
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3991Références
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