Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
12 2020
Historique:
received: 18 11 2019
accepted: 19 02 2020
revised: 17 02 2020
pubmed: 7 3 2020
medline: 5 1 2021
entrez: 6 3 2020
Statut: ppublish

Résumé

Hyperleukocytosis in acute myeloid leukemia (AML) is associated with inferior outcomes. There is limited high quality evidence to support the benefits of leukapheresis. We retrospectively collected data from patients with newly-diagnosed AML who presented with a white cell count (WBC) >50 × 10

Identifiants

pubmed: 32132655
doi: 10.1038/s41375-020-0783-3
pii: 10.1038/s41375-020-0783-3
pmc: PMC8155811
mid: NIHMS1564245
doi:

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3149-3160

Subventions

Organisme : NCATS NIH HHS
ID : KL2 TR002002
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009512
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016359
Pays : United States

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Auteurs

Maximilian Stahl (M)

Department of Internal Medicine Section of Hematology, Yale School of Medicine, New Haven, CT, USA.

Rory M Shallis (RM)

Department of Internal Medicine Section of Hematology, Yale School of Medicine, New Haven, CT, USA.

Wei Wei (W)

Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.

Pau Montesinos (P)

Hospital Universitario y Politecnico La Fe, Valencia, Spain; & CIBERONC, Instituto Carlos III, University of Valencia, Madrid, Spain.

Etienne Lengline (E)

Hematology Department, Saint-Louis Hospital AP-HP, Paris, France.

Judith Neukirchen (J)

Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.

Vijaya R Bhatt (VR)

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Mikkael A Sekeres (MA)

Leukemia Program, Cleveland Clinic, Cleveland, OH, USA.

Amir T Fathi (AT)

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

Heiko Konig (H)

Indiana University Simon Cancer Center, Indianapolis, IN, USA.

Selina Luger (S)

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

Irum Khan (I)

University of Illinois Cancer Center, Chicago, IL, USA.

Gail J Roboz (GJ)

Weill Cornell Medicine and The New York Presbyterian Hospital, New York, NY, USA.

Thomas Cluzeau (T)

CHU of Nice, Hematology Department, Cote d'Azur University, Nice, France.

David Martínez-Cuadron (D)

Hospital Universitario y Politecnico La Fe, Valencia, Spain; & CIBERONC, Instituto Carlos III, University of Valencia, Madrid, Spain.

Emmanuel Raffoux (E)

Hematology Department, Saint-Louis Hospital AP-HP, Paris, France.

Ulrich Germing (U)

Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.

Jayadev Manikkam Umakanthan (JM)

University of North Carolina Physician Network, Durham, NC, USA.

Sudipto Mukherjee (S)

Leukemia Program, Cleveland Clinic, Cleveland, OH, USA.

Andrew M Brunner (AM)

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

Adam Miller (A)

Indiana University Simon Cancer Center, Indianapolis, IN, USA.

Christine M McMahon (CM)

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

Ellen K Ritchie (EK)

University of Illinois Cancer Center, Chicago, IL, USA.

Rebeca Rodríguez-Veiga (R)

Hospital Universitario y Politecnico La Fe, Valencia, Spain; & CIBERONC, Instituto Carlos III, University of Valencia, Madrid, Spain.

Raphaël Itzykson (R)

Hematology Department, Saint-Louis Hospital AP-HP, Paris, France.

Blanca Boluda (B)

Hospital Universitario y Politecnico La Fe, Valencia, Spain; & CIBERONC, Instituto Carlos III, University of Valencia, Madrid, Spain.

Florence Rabian (F)

Hospital Universitario y Politecnico La Fe, Valencia, Spain; & CIBERONC, Instituto Carlos III, University of Valencia, Madrid, Spain.
Hematology Department, Saint-Louis Hospital AP-HP, Paris, France.

Mar Tormo (M)

INCLIVA, University Clinical Hospital, Valencia, Spain.

Evelyn Acuña-Cruz (E)

Hospital Universitario y Politecnico La Fe, Valencia, Spain; & CIBERONC, Instituto Carlos III, University of Valencia, Madrid, Spain.

Emma Rabinovich (E)

University of Illinois Cancer Center, Chicago, IL, USA.

Brendan Yoo (B)

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

Isabel Cano (I)

Hospital Universitario y Politecnico La Fe, Valencia, Spain; & CIBERONC, Instituto Carlos III, University of Valencia, Madrid, Spain.

Nikolai A Podoltsev (NA)

Department of Internal Medicine Section of Hematology, Yale School of Medicine, New Haven, CT, USA.

Jan Philipp Bewersdorf (JP)

Department of Internal Medicine Section of Hematology, Yale School of Medicine, New Haven, CT, USA.

Steven Gore (S)

Department of Internal Medicine Section of Hematology, Yale School of Medicine, New Haven, CT, USA.

Amer M Zeidan (AM)

Department of Internal Medicine Section of Hematology, Yale School of Medicine, New Haven, CT, USA. amer.zeidan@yale.edu.

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