Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation.
TARDBP
amyotrophic lateral sclerosis
cellular model
chaperone mediated autophagy
lysosomal damage
protein aggregation
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
08
2019
accepted:
21
01
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
7
3
2020
Statut:
epublish
Résumé
TAR DNA binding protein 43 kDa (TDP-43) is a ribonuclear protein regulating many aspects of RNA metabolism. Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) are fatal neurodegenerative diseases with the presence of TDP-43 aggregates in neuronal cells. Chaperone Mediated Autophagy (CMA) is a lysosomal degradation pathway participating in the proteostasis of several cytosolic proteins including neurodegenerative associated proteins. In addition, protein oligomers or aggregates can affect the status of CMA. In this work, we studied the relationship between CMA and the physiological and pathological forms of TDP-43. First, we found that recombinant TDP-43 was specifically degraded by rat liver's CMA+ lysosomes and that endogenous TDP-43 is localized in rat brain's CMA+ lysosomes, indicating that TDP-43 can be a CMA substrate
Identifiants
pubmed: 32132902
doi: 10.3389/fnmol.2020.00019
pmc: PMC7040037
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19Informations de copyright
Copyright © 2020 Ormeño, Hormazabal, Moreno, Riquelme, Rios, Criollo, Albornoz, Alfaro and Budini.
Références
J Biol Chem. 2012 Mar 2;287(10):7512-25
pubmed: 22235134
Methods Mol Biol. 2008;445:227-44
pubmed: 18425454
J Cell Sci. 2014 Jul 15;127(Pt 14):3024-38
pubmed: 24860144
Nature. 2006 Jun 15;441(7095):880-4
pubmed: 16625205
J Neurochem. 2016 Aug;138 Suppl 1:95-111
pubmed: 27015757
J Biol Chem. 2008 Aug 29;283(35):23542-56
pubmed: 18566453
Traffic. 2000 Jul;1(7):570-83
pubmed: 11208145
Autophagy. 2008 Nov;4(8):1101-3
pubmed: 18927485
J Biol Chem. 1993 Nov 5;268(31):23490-5
pubmed: 8226876
Methods Enzymol. 1990;182:203-25
pubmed: 2156127
Methods Mol Biol. 2019;1880:703-727
pubmed: 30610733
J Cell Biol. 2009 Dec 28;187(7):1083-99
pubmed: 20026656
Methods Enzymol. 2009;452:297-324
pubmed: 19200890
PLoS One. 2013 Apr 25;8(4):e62143
pubmed: 23634225
Sci Rep. 2017 Aug 9;7(1):7690
pubmed: 28794446
J Virol. 1995 Jun;69(6):3584-96
pubmed: 7745706
Trends Mol Med. 2014 Feb;20(2):66-71
pubmed: 24355761
Trends Biochem Sci. 2012 Jun;37(6):237-47
pubmed: 22534659
J Neurosci Res. 2010 Mar;88(4):784-97
pubmed: 19798749
Autophagy. 2016 Aug 2;12(8):1215-28
pubmed: 27171370
Trends Biochem Sci. 1990 Aug;15(8):305-9
pubmed: 2204156
J Cell Biol. 1997 May 19;137(4):825-34
pubmed: 9151685
J Biol Chem. 2001 Sep 28;276(39):36337-43
pubmed: 11470789
Genes Dev. 2012 Aug 1;26(15):1679-84
pubmed: 22855830
Transl Neurodegener. 2019 Jun 15;8:18
pubmed: 31223479
Am J Physiol. 1995 Nov;269(5 Pt 1):C1200-8
pubmed: 7491910
Dev Cell. 2011 Jan 18;20(1):131-9
pubmed: 21238931
J Biol Chem. 1997 Feb 28;272(9):5606-15
pubmed: 9038169
Nature. 2006 Jun 15;441(7095):885-9
pubmed: 16625204
Nat Rev Mol Cell Biol. 2018 Jun;19(6):365-381
pubmed: 29626215
EMBO J. 2009 Apr 8;28(7):889-901
pubmed: 19229298
Adv Genet. 2009;66:1-34
pubmed: 19737636
J Cell Biol. 2016 Mar 14;212(6):677-92
pubmed: 26975849
J Biol Chem. 1989 Dec 25;264(36):21591-6
pubmed: 2689440
Autophagy. 2007 Jul-Aug;3(4):295-9
pubmed: 17404494
Nat Rev Neurosci. 2011 Nov 30;13(1):38-50
pubmed: 22127299
Biochem Soc Trans. 2013 Dec;41(6):1483-8
pubmed: 24256241
Brain Res. 2018 Mar 15;1683:12-16
pubmed: 29456132
EMBO Rep. 2011 Feb;12(2):149-56
pubmed: 21252941
Aging Cell. 2015 Apr;14(2):249-64
pubmed: 25620427
Front Aging Neurosci. 2018 May 08;10:130
pubmed: 29867441
J Cell Sci. 2014 Mar 15;127(Pt 6):1263-78
pubmed: 24424030
Biochem J. 1991 Apr 1;275 ( Pt 1):165-9
pubmed: 2018472
Neurosci Lett. 2010 Jan 18;469(1):112-6
pubmed: 19944744
Brain Pathol. 2018 Jan;28(1):3-13
pubmed: 28703923
Nat Commun. 2011 Jul 12;2:386
pubmed: 21750540
Nat Neurosci. 2013 Apr;16(4):394-406
pubmed: 23455607
Science. 1996 Jul 26;273(5274):501-3
pubmed: 8662539
Hum Mol Genet. 2015 Jan 1;24(1):9-20
pubmed: 25122661
PLoS One. 2009;4(5):e5515
pubmed: 19436756
Sci Rep. 2018 Apr 16;8(1):6030
pubmed: 29662239
Hum Mol Genet. 2009 Nov 1;18(21):4153-70
pubmed: 19654187
J Microsc. 2006 Dec;224(Pt 3):213-32
pubmed: 17210054
J Neurosci. 2011 Dec 14;31(50):18492-505
pubmed: 22171050
J Biol Chem. 1994 Oct 21;269(42):26374-80
pubmed: 7929357
Autophagy. 2015;11(8):1408-24
pubmed: 26114578
Autophagy. 2010 Jan;6(1):182-3
pubmed: 20023429
Mov Disord. 2015 Nov;30(13):1830-4
pubmed: 26769460
J Biol Chem. 2010 Apr 30;285(18):13621-9
pubmed: 20200163
Curr Opin Cell Biol. 2011 Apr;23(2):184-9
pubmed: 21094035
PLoS One. 2012;7(10):e46834
pubmed: 23071649
Nat Rev Mol Cell Biol. 2013 Dec;14(12):759-74
pubmed: 24201109
Aging Cell. 2018 Feb;17(1):
pubmed: 29024336
Methods. 2015 Mar;75:133-40
pubmed: 25595300