Brain Resting-State Network Alterations Associated With Crohn's Disease.
Crohn's disease (CD)
functional connectivity (FC)
functional magnetic resonance imaging (fMRI)
inflammatory bowel disease (IBD)
resting-state networks (RSNs)
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
11
2019
accepted:
14
01
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
7
3
2020
Statut:
epublish
Résumé
Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses.
Identifiants
pubmed: 32132964
doi: 10.3389/fneur.2020.00048
pmc: PMC7040490
doi:
Types de publication
Journal Article
Langues
eng
Pagination
48Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK048351
Pays : United States
Informations de copyright
Copyright © 2020 Kornelsen, Wilson, Labus, Witges, Mayer and Bernstein.
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