Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia.
STAT3
STAT5b
T-LGL leukemia (T-LGLL)
chronic lymphoproliferative disease of NK cells (CLPD-NK)
large granular lymphocyte (LGL)
mutation
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
11
2019
accepted:
28
01
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
7
3
2020
Statut:
epublish
Résumé
Large granular lymphocyte leukemia (LGLL) is a chronic proliferation of clonal cytotoxic lymphocytes, usually presenting with cytopenias and yet lacking a specific therapy. The disease is heterogeneous, including different subsets of patients distinguished by LGL immunophenotype (CD8+ Tαβ, CD4+ Tαβ, Tγδ, NK) and the clinical course of the disease (indolent/symptomatic/aggressive). Even if the etiology of LGLL remains elusive, evidence is accumulating on the genetic landscape driving and/or sustaining chronic LGL proliferations. The most common gain-of-function mutations identified in LGLL patients are on
Identifiants
pubmed: 32133291
doi: 10.3389/fonc.2020.00152
pmc: PMC7040228
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
152Informations de copyright
Copyright © 2020 Teramo, Barilà, Calabretto, Vicenzetto, Gasparini, Semenzato and Zambello.
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