Sequential Surgical Procedures in Vascular Surgery Patients Are Associated With Perioperative Adverse Cardiac Events.

cardiac adverse event interleukin-6 perioperative inflammation plaque vulnerability regulatory T cells vascular surgery

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2020
Historique:
received: 01 08 2019
accepted: 28 01 2020
entrez: 6 3 2020
pubmed: 7 3 2020
medline: 7 3 2020
Statut: epublish

Résumé

Patients at elevated cardiovascular risk are prone to perioperative cardiovascular complications, like myocardial injury after non-cardiac surgery (MINS). We have demonstrated in a mouse model of atherosclerosis that perioperative stress leads to an increase in plaque volume and higher plaque vulnerability. Regulatory T cells (Tregs) play a pivotal role in development and destabilization of atherosclerotic plaques. For this exploratory

Identifiants

pubmed: 32133374
doi: 10.3389/fcvm.2020.00013
pmc: PMC7040239
doi:

Types de publication

Journal Article

Langues

eng

Pagination

13

Informations de copyright

Copyright © 2020 Janssen, Felgner, Kummer, Gillmann, Schrimpf, Rustum, Lichtinghagen, Sahlmann, Weigand, Teebken, Theilmeier and Larmann.

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Auteurs

Henrike Janssen (H)

Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.
Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hanover, Germany.

Larissa Felgner (L)

Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.

Laura Kummer (L)

Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.

Hans-Jörg Gillmann (HJ)

Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hanover, Germany.

Claudia Schrimpf (C)

Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany.

Saad Rustum (S)

Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany.

Ralf Lichtinghagen (R)

Institute for Clinical Chemistry, Medical School Hannover, Hanover, Germany.

Bianca Sahlmann (B)

Department of Human Medicine, Perioperative Inflammation and Infection, Faculty of Medicine and Health Sciences, University of Oldenburg, Oldenburg, Germany.

Markus A Weigand (MA)

Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.

Omke E Teebken (OE)

Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany.

Gregor Theilmeier (G)

Department of Human Medicine, Perioperative Inflammation and Infection, Faculty of Medicine and Health Sciences, University of Oldenburg, Oldenburg, Germany.
Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.

Jan Larmann (J)

Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.
Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hanover, Germany.

Classifications MeSH