Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites.
Mechanism of action
Proteins
Journal
NPJ science of food
ISSN: 2396-8370
Titre abrégé: NPJ Sci Food
Pays: England
ID NLM: 101739627
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
09
2019
accepted:
27
01
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
7
3
2020
Statut:
epublish
Résumé
Sesamin [(7α,7'α,8α,8'α)-3,4:3',4'-bis(methylenedioxy)-7,9':7',9-diepoxylignane] is a major lignan in sesame seeds. Sesamin is converted to the catechol metabolite, SC1 [(7α,7'α,8α,8'α)-3',4'-methylenedioxy-7,9':7',9-diepoxylignane-3,4-diol] with anti-inflammatory effects after oral administration. However, its molecular target remains unknown. Analysis using high-performance affinity nanobeads led to the identification of annexin A1 (ANX A1) as an SC1-binding protein. SC1 was found to bind to the annexin repeat 3 region of ANX A1 with a high-affinity constant (Kd = 2.77 μmol L
Identifiants
pubmed: 32133417
doi: 10.1038/s41538-020-0064-6
pii: 64
pmc: PMC7033200
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsD.T., Y.O., S.A., Y.K., T.R. and H.S. are employees of Suntory Wellness Ltd, which is a manufacturer of foods that contain sesamin. All authors declare no other competing interests.
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