Cold aggravates abnormal excitability of motor axons in oxaliplatin-treated patients.
Aged
Antineoplastic Agents
/ adverse effects
Axons
/ drug effects
Cold Temperature
/ adverse effects
Colonic Neoplasms
/ drug therapy
Female
Follow-Up Studies
Humans
Hyperalgesia
/ chemically induced
Male
Middle Aged
Motor Neurons
/ drug effects
Oxaliplatin
/ adverse effects
Prospective Studies
Treatment Outcome
allodynia
nerve excitability testing
neuropathy
oxaliplatin toxicity
potassium channel dysfunction
sodium channel dysfunction
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
19
10
2019
revised:
26
02
2020
accepted:
29
02
2020
pubmed:
7
3
2020
medline:
30
7
2020
entrez:
6
3
2020
Statut:
ppublish
Résumé
Cold allodynia is often seen in the acute phase of oxaliplatin treatment, but the underlying pathophysiology remains unclear. Patients scheduled for adjuvant oxaliplatin for colorectal cancer were examined with quantitative sensory testing and nerve excitability tests at baseline and after the second or third oxaliplatin cycle at different skin temperatures. Seven patients were eligible for examination. All patients felt evoked pain and tingling when touching something cold after oxaliplatin infusion. Oxaliplatin decreased motor nerve superexcitability (P < .001), increased relative refractory period (P = .011), and caused neuromyotonia-like after-activity. Cooling exacerbated these changes and prolonged the accommodation half-time. The findings suggest that a combined effect of oxaliplatin and cooling facilitates nerve excitability changes and neuromyotonia-like after-activity in peripheral nerve axons. A possible mechanism is the slowing in gating of voltage-dependent fast sodium and slow potassium channels, which results in symptoms of cold allodynia.
Identifiants
pubmed: 32133655
doi: 10.1002/mus.26852
pmc: PMC7318596
doi:
Substances chimiques
Antineoplastic Agents
0
Oxaliplatin
04ZR38536J
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
796-800Informations de copyright
© 2020 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc.
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