Understanding the impact of bilateral brain injury in children with unilateral cerebral palsy.
Adolescent
Brain Injuries
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Cerebral Palsy
/ diagnostic imaging
Child
Child, Preschool
Cohort Studies
Corpus Callosum
/ diagnostic imaging
Female
Functional Laterality
/ physiology
Gray Matter
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Neuroimaging
/ methods
Thalamus
/ diagnostic imaging
White Matter
/ diagnostic imaging
bilateral
cerebral palsy
interventions
magnetic resonance imaging
plasticity
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
09
07
2019
revised:
27
01
2020
accepted:
23
02
2020
pubmed:
7
3
2020
medline:
9
11
2021
entrez:
6
3
2020
Statut:
ppublish
Résumé
The presence of bilateral brain injury in patients with unilateral cerebral palsy (CP) may impact neuroplasticity in the ipsilateral hemisphere; however, this pattern of injury is typically under-analyzed due to the lack of methods robust to severe injury. In this study, injury-robust methods have been applied to structural brain magnetic resonance imaging (MRI) data of a cohort of 91 children with unilateral CP (37 with unilateral and 54 with bilateral brain injury, 4-17 years) and 44 typically developing controls (5-17 years), to determine how brain structure is associated with concurrent motor function, and if these associations differ between patients with unilateral or bilateral injury. Regression models were used to associate these measures with two clinical scores of hand function, with patient age, gender, brain injury laterality, and interaction effects included. Significant associations with brain structure and motor function were observed (Pearson's r = .494-.716), implicating several regions of the motor pathway, and demonstrating an accurate prediction of hand function from MRI, regardless of the extent of brain injury. Reduced brain volumes were observed in patients with bilateral injury, including volumes of the thalamus and corpus callosum splenium, compared to those with unilateral injury, and the healthy controls. Increases in cortical thickness in several cortical regions were observed in cohorts with unilateral and bilateral injury compared to controls, potentially suggesting neuroplasticity might be occurring in the inferior frontal gyrus and the precuneus. These findings identify prospective useful target regions for transcranial magnetic stimulation intervention.
Identifiants
pubmed: 32134174
doi: 10.1002/hbm.24978
pmc: PMC7294067
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2794-2807Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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