Fetuin-A in Metabolic syndrome: A systematic review and meta-analysis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
09
2019
accepted:
13
02
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
23
6
2020
Statut:
epublish
Résumé
Fetuin-A has been associated with the progression of metabolic syndrome, but previous studies found inconsistent results on the relationship between metabolic syndrome and the concentration of fetuin-A. The aim of this study was to perform a meta-analysis to summarize previous findings on this relationship. This study was registered with the International Prospective Register of Systematic Reviews PROSPERO (CRD42019129566). Studies examining the relationship between metabolic syndrome and the concentration of circulating fetuin-A were identified using a systematic search in the electronic databases of Embase, PubMed, Web of Science, and Cochrane Library before March 2019. A random effects model was used to summarize the effect size of the association in terms of the standardized mean difference (SMD). Fourteen eligible studies compared fetuin-A concentrations between 4,551 metabolic syndrome patients and 8,805 controls. The circulating fetuin-A concentration was significantly higher in the metabolic syndrome patients than in the controls (SMD = 0.65, 95% confidence interval (CI): 0.48 to 0.83, Z = 7.18, p<0.001). Besides, circulating fetuin-A was a risk factor for metabolic syndrome (odds ratio 1.23, 95% CI: 1.08 to 1.40). These findings suggest that fetuin-A may be an important indicator for metabolic syndrome, in which case this may lead to new perspectives in early diagnosis, identification of novel biomarkers, and providing novel targets for pharmacological interventions.
Identifiants
pubmed: 32134969
doi: 10.1371/journal.pone.0229776
pii: PONE-D-19-25120
pmc: PMC7058339
doi:
Substances chimiques
AHSG protein, human
0
Biomarkers
0
alpha-2-HS-Glycoprotein
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0229776Subventions
Organisme : CIHR
ID : FDN-148438
Pays : Canada
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Lipids Health Dis. 2019 Jan 22;18(1):23
pubmed: 30670052
Egypt J Immunol. 2018 Jan;25(1):191-202
pubmed: 30243011
Contemp Clin Trials. 2015 Nov;45(Pt A):139-45
pubmed: 26343745
BMC Psychiatry. 2018 Oct 5;18(1):324
pubmed: 30290789
J Diabetes Res. 2017;2017:1492581
pubmed: 28770230
Metab Syndr Relat Disord. 2013 Dec;11(6):377-84
pubmed: 23971757
Am J Nephrol. 2008;28(4):669-76
pubmed: 18337634
Diabetologia. 2014 May;57(5):1057-66
pubmed: 24493202
PeerJ. 2018 Jun 12;6:e4884
pubmed: 29910974
J Clin Endocrinol Metab. 2012 Oct;97(10):E1943-7
pubmed: 22855337
Int J Obes (Lond). 2015 May;39(5):734-41
pubmed: 25468829
J Clin Lab Anal. 2013 Jul;27(4):317-22
pubmed: 23852792
Circulation. 2006 Apr 11;113(14):1760-7
pubmed: 16567568
PLoS One. 2014 Mar 18;9(3):e92238
pubmed: 24643166
J Pediatr Endocrinol Metab. 2016 Nov 1;29(11):1277-1283
pubmed: 27754964
Atherosclerosis. 2015 Jul;241(1):130-7
pubmed: 25978344
Eur J Epidemiol. 2010 Sep;25(9):603-5
pubmed: 20652370
Ther Adv Endocrinol Metab. 2018 Aug 18;9(12):329-338
pubmed: 30515292
J Agric Food Chem. 2018 Jul 5;66(26):6772-6781
pubmed: 29886733
J Am Heart Assoc. 2017 Jul 16;6(7):
pubmed: 28713076
Diabetes Care. 2013 Oct;36(10):3121-7
pubmed: 23801724
PLoS One. 2011;6(8):e23556
pubmed: 21886796
Am J Cardiol. 2010 Jun 15;105(12):1666-72
pubmed: 20538112
World J Diabetes. 2019 Jan 15;10(1):23-36
pubmed: 30697368
Biochem Pharmacol. 2013 Oct 1;86(7):960-9
pubmed: 23948064
Biochem J. 2010 Aug 1;429(3):451-62
pubmed: 20482516
PLoS One. 2008 Mar 12;3(3):e1765
pubmed: 18335040
Atherosclerosis. 2011 May;216(1):180-6
pubmed: 21310413
Rheumatology (Oxford). 2008 Jul;47(7):1031-7
pubmed: 18448482
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Diabetes Res Clin Pract. 2014 Oct;106(1):128-35
pubmed: 25110104
Int J Mol Sci. 2019 Feb 02;20(3):
pubmed: 30717377
BMJ. 2009 Jul 21;339:b2535
pubmed: 19622551
Front Mol Neurosci. 2018 Dec 04;11:450
pubmed: 30564100
J Endocrinol Invest. 2018 Jan;41(1):33-47
pubmed: 28643299
Endocrinology. 2012 Jul;153(7):2974-84
pubmed: 22619360
Arch Med Sci. 2012 Nov 9;8(5):826-33
pubmed: 23185191
Clin Endocrinol (Oxf). 2014 Aug;81(2):197-203
pubmed: 23899227
Exp Clin Endocrinol Diabetes. 2014 Jun;122(6):363-7
pubmed: 24941433
Endocrine. 2017 Oct;58(1):190-193
pubmed: 28779425
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120