Inter-Organelle Membrane Contact Sites and Mitochondrial Quality Control during Aging: A Geroscience View.
biomarkers
exosomes
extracellular vesicles
geroprotective interventions
mitochondrial damage
mitochondrial dynamics
mitochondrial-derived vesicles
mitochondrial-lysosomal axis
mitophagy
neurodegeneration
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
received:
17
02
2020
revised:
28
02
2020
accepted:
29
02
2020
entrez:
7
3
2020
pubmed:
7
3
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Mitochondrial dysfunction and failing mitochondrial quality control (MQC) are major determinants of aging. Far from being standalone organelles, mitochondria are intricately related with cellular other compartments, including lysosomes. The intimate relationship between mitochondria and lysosomes is reflected by the fact that lysosomal degradation of dysfunctional mitochondria is the final step of mitophagy. Inter-organelle membrane contact sites also allow bidirectional communication between mitochondria and lysosomes as part of nondegradative pathways. This interaction establishes a functional unit that regulates metabolic signaling, mitochondrial dynamics, and, hence, MQC. Contacts of mitochondria with the endoplasmic reticulum (ER) have also been described. ER-mitochondrial interactions are relevant to Ca
Identifiants
pubmed: 32138154
pii: cells9030598
doi: 10.3390/cells9030598
pmc: PMC7140483
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
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