Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.
Parkinson’s disease, α-synuclein
aggregation
neurodegeneration
therapy
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
received:
29
01
2020
revised:
26
02
2020
accepted:
29
02
2020
entrez:
7
3
2020
pubmed:
7
3
2020
medline:
19
3
2021
Statut:
epublish
Résumé
Parkinson's Disease (PD) is characterized both by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy Bodies contain the aggregated α-synuclein (α-syn) protein, which has been shown to be able to propagate from cell to cell and throughout different regions in the brain. Due to its central role in the pathology and the lack of a curative treatment for PD, an increasing number of studies have aimed at targeting this protein for therapeutics. Here, we reviewed and discussed the many different approaches that have been studied to inhibit α-syn accumulation via direct and indirect targeting. These analyses have led to the generation of multiple clinical trials that are either completed or currently active. These clinical trials and the current preclinical studies must still face obstacles ahead, but give hope of finding a therapy for PD with time.
Identifiants
pubmed: 32138193
pii: biom10030391
doi: 10.3390/biom10030391
pmc: PMC7175302
pii:
doi:
Substances chimiques
Protein Aggregates
0
SNCA protein, human
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondation de France Grant
ID : 00066525
Pays : International
Organisme : France Parkinson Grant
ID : 2019-000467
Pays : International
Organisme : IDEX Emergence Grant number
ID : OPE-2018-410
Pays : International
Organisme : ANR Grant
ID : ANR-17-CE18-0026-01
Pays : International
Organisme : IMPRiND grant
ID : 116060
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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