The role of mitochondria-associated membranes in cellular homeostasis and diseases.
Autophagy
Calcium transfer apoptosis
Cancer
Diabetes
Inflammation and antiviral response
Lipid trafficking and metabolism
Mitochondrial dynamics
Neurodegenerative diseases
ROS
Journal
International review of cell and molecular biology
ISSN: 1937-6448
Titre abrégé: Int Rev Cell Mol Biol
Pays: Netherlands
ID NLM: 101475846
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
7
3
2020
pubmed:
7
3
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that multiple scaffold proteins and regulatory factors localize to this subcellular fraction suggesting MAMs as hotspot signaling domains. In this review we describe the current knowledge about MAMs' dynamics and processes, which provided new correlations between MAMs' dysfunctions and human diseases. In fact, MAMs machinery is strictly connected with several pathologies, like neurodegeneration, diabetes and mainly cancer. These pathological events are characterized by alterations in the normal communication between ER and mitochondria, leading to deep metabolic defects that contribute to the progression of the diseases.
Identifiants
pubmed: 32138899
pii: S1937-6448(19)30104-2
doi: 10.1016/bs.ircmb.2019.11.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-196Informations de copyright
© 2020 Elsevier Inc. All rights reserved.