A central master driver of psychosocial stress responses in the rat.
Animals
Dorsomedial Hypothalamic Nucleus
/ metabolism
Emotions
/ physiology
Female
Glutamic Acid
/ metabolism
Homeostasis
Male
Neurons
/ metabolism
Prefrontal Cortex
/ metabolism
Prosencephalon
/ metabolism
Psychophysiologic Disorders
/ therapy
Rats
Rats, Inbred LEC
Rats, Wistar
Signal Transduction
Social Behavior
Stress, Psychological
/ metabolism
Vesicular Glutamate Transport Protein 1
/ metabolism
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
06 03 2020
06 03 2020
Historique:
received:
12
09
2019
accepted:
04
02
2020
entrez:
7
3
2020
pubmed:
7
3
2020
medline:
20
3
2020
Statut:
ppublish
Résumé
The mechanism by which psychological stress elicits various physiological responses is unknown. We discovered a central master neural pathway in rats that drives autonomic and behavioral stress responses by connecting the corticolimbic stress circuits to the hypothalamus. Psychosocial stress signals from emotion-related forebrain regions activated a VGLUT1-positive glutamatergic pathway from the dorsal peduncular cortex and dorsal tenia tecta (DP/DTT), an unexplored prefrontal cortical area, to the dorsomedial hypothalamus (DMH), a hypothalamic autonomic center. Genetic ablation and optogenetics revealed that the DP/DTT→DMH pathway drives thermogenic, hyperthermic, and cardiovascular sympathetic responses to psychosocial stress without contributing to basal homeostasis. This pathway also mediates avoidance behavior from psychosocial stressors. Given the variety of stress responses driven by the DP/DTT→DMH pathway, the DP/DTT can be a potential target for treating psychosomatic disorders.
Identifiants
pubmed: 32139538
pii: 367/6482/1105
doi: 10.1126/science.aaz4639
doi:
Substances chimiques
Slc17a7 protein, rat
0
Vesicular Glutamate Transport Protein 1
0
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1105-1112Subventions
Organisme : Medical Research Foundation
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.