The greater inflammatory pathway-high clinical potential by innovative predictive, preventive, and personalized medical approach.
Autonomic nervous system
Big data analysis
Epigenetics
Genetics
Individualized patient profile
Inflammation
Machine learning
Mechanotransduction
Multi-omics
Network science
Neuro-immuno modulation
Non-communicable diseases
Patient stratification
Phenotyping
Predictive
Risk
Wound healing
and personalized medicine
modifiable
preventable factors
preventive
Journal
The EPMA journal
ISSN: 1878-5077
Titre abrégé: EPMA J
Pays: Switzerland
ID NLM: 101517307
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
31
10
2019
accepted:
13
11
2019
entrez:
7
3
2020
pubmed:
7
3
2020
medline:
7
3
2020
Statut:
epublish
Résumé
Impaired wound healing (WH) and chronic inflammation are hallmarks of non-communicable diseases (NCDs). However, despite WH being a recognized player in NCDs, mainstream therapies focus on (un)targeted damping of the inflammatory response, leaving WH largely unaddressed, owing to three main factors. The first is the complexity of the pathway that links inflammation and wound healing; the second is the dual nature, local and systemic, of WH; and the third is the limited acknowledgement of genetic and contingent causes that disrupt physiologic progression of WH. Here, in the frame of Predictive, Preventive, and Personalized Medicine (PPPM), we integrate and revisit current literature to offer a novel systemic view on the cues that can impact on the fate (acute or chronic inflammation) of WH, beyond the compartmentalization of medical disciplines and with the support of advanced computational biology. This shall open to a broader understanding of the causes for WH going awry, offering new operational criteria for patients' stratification (prediction and personalization). While this may also offer improved options for targeted prevention, we will envisage new therapeutic strategies to reboot and/or boost WH, to enable its progression across its physiological phases, the first of which is a transient acute inflammatory response versus the chronic low-grade inflammation characteristic of NCDs.
Sections du résumé
BACKGROUND AND LIMITATIONS
UNASSIGNED
Impaired wound healing (WH) and chronic inflammation are hallmarks of non-communicable diseases (NCDs). However, despite WH being a recognized player in NCDs, mainstream therapies focus on (un)targeted damping of the inflammatory response, leaving WH largely unaddressed, owing to three main factors. The first is the complexity of the pathway that links inflammation and wound healing; the second is the dual nature, local and systemic, of WH; and the third is the limited acknowledgement of genetic and contingent causes that disrupt physiologic progression of WH.
PROPOSED APPROACH
UNASSIGNED
Here, in the frame of Predictive, Preventive, and Personalized Medicine (PPPM), we integrate and revisit current literature to offer a novel systemic view on the cues that can impact on the fate (acute or chronic inflammation) of WH, beyond the compartmentalization of medical disciplines and with the support of advanced computational biology.
CONCLUSIONS
CONCLUSIONS
This shall open to a broader understanding of the causes for WH going awry, offering new operational criteria for patients' stratification (prediction and personalization). While this may also offer improved options for targeted prevention, we will envisage new therapeutic strategies to reboot and/or boost WH, to enable its progression across its physiological phases, the first of which is a transient acute inflammatory response versus the chronic low-grade inflammation characteristic of NCDs.
Identifiants
pubmed: 32140182
doi: 10.1007/s13167-019-00195-w
pii: 195
pmc: PMC7028895
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1-16Informations de copyright
© European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2019.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interest.
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