PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [
Beta-secretase 1 (BACE1)
Dosimetry
Human brain
Positron emission tomography (PET)
Test-retest repeatability
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
28
11
2019
accepted:
20
02
2020
pubmed:
7
3
2020
medline:
15
5
2021
entrez:
7
3
2020
Statut:
ppublish
Résumé
Beta-secretase 1 (BACE1) enzyme is implicated in the pathophysiology of Alzheimer's disease. [ Five subjects were studied for the dosimetry study. Whole-body PET was performed for 366 min with 4 PET-CT sessions. Estimates of the absorbed radiation dose were calculated using the male adult model. Eight subjects participated in the test-retest study. Brain PET measurements were conducted for 123 min with an interval of 5 to 19 days between test and retest conditions. The total distribution volume (V In the dosimetry study, the highest uptake was found in the liver (25.2 ± 2.3 %ID at 0.5 h) and the largest dose was observed in the pancreas (92.9 ± 52.2 μSv/MBq). The calculated ED was 24.7 ± 0.8 μSv/MBq. In the test-retest study, 2TCM described the time-activity curves well. V The ED of [ EudraCT 2016-001110-19 (registered 2016-08-08).
Identifiants
pubmed: 32140803
doi: 10.1007/s00259-020-04739-5
pii: 10.1007/s00259-020-04739-5
pmc: PMC7396399
doi:
Substances chimiques
Radiopharmaceuticals
0
Amyloid Precursor Protein Secretases
EC 3.4.-
Aspartic Acid Endopeptidases
EC 3.4.23.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2429-2439Références
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