Clinico-diagnostic features of neuralgic amyotrophy in childhood.


Journal

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 04 11 2019
accepted: 21 02 2020
pubmed: 7 3 2020
medline: 15 5 2021
entrez: 7 3 2020
Statut: ppublish

Résumé

Neuralgic amyotrophy (NA), even known as Personage-Turner's syndrome (PTS), is a neurologic condition, affecting the lower motor neurons of brachial plexus and/or individual nerves or nerve branches, characterized by pain, muscle weakness/atrophy, and sensory symptoms. NA has an acute/subacute onset, after an infection or vaccination; it is more common in male and is rare in the pediatric population. The etiology remains uncertain, being considered heterogeneous and multifactorial. A severe acute neurologic pain around the shoulder girdle is the classic presenting symptom at onset. As the pain subsides, weakness and paresis develop. NA is usually unilateral, but sometimes, a subclinical contralateral limb involvement could be present and bilateral affection has been described. The diagnosis is clinical, through a comprehensive history and neurological examination. However, electrophysiological testing and imaging are critical, because there is no diagnostic test for PTS and it remains a diagnosis of exclusion. Upper brachial plexus peripheral involvement with weakness of periscapular and perihumeral muscles is the classic presentation, associated with electrophysiological evidence of denervation in the affected muscles. Imaging, laboratory, and genetic testing can be useful for the differential diagnosis. NA is in most cases a self-limiting condition, and it is characterized by good recovery. Treatment of NA usually involves a combination of corticosteroids, analgesics, immobilization, and physical therapy, even if limited data are available in children. Physiotherapy is required to maintain muscle strength.

Identifiants

pubmed: 32140911
doi: 10.1007/s10072-020-04314-8
pii: 10.1007/s10072-020-04314-8
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1735-1740

Auteurs

Eleonora Rotondo (E)

Department of Paediatrics, "G. d'Annunzio" University, Chieti, Italy.

Noemi Pellegrino (N)

Department of Paediatrics, "G. d'Annunzio" University, Chieti, Italy.

Caterina Di Battista (C)

Department of Paediatrics, "G. d'Annunzio" University, Chieti, Italy.

Alessandro Graziosi (A)

Department of Paediatrics, "G. d'Annunzio" University, Chieti, Italy.

Vincenzo Di Stefano (V)

Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University, Via dei Vestini, 66013, Chieti, Italy. vincenzo19689@gmail.com.

Pasquale Striano (P)

Paediatric Neurology and Muscular Diseases Unit, "G. Gaslini" Institute, Genoa, Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.

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Classifications MeSH