Effects of Colchicine on Atherosclerotic Plaque Stabilization: a Multimodality Imaging Study in an Animal Model.
Animals
Aorta, Abdominal
/ diagnostic imaging
Aortic Diseases
/ diagnosis
Colchicine
/ therapeutic use
Disease Models, Animal
Gout Suppressants
/ therapeutic use
Magnetic Resonance Imaging, Cine
/ methods
Male
Multimodal Imaging
/ methods
Plaque, Atherosclerotic
/ diagnosis
Positron-Emission Tomography
/ methods
Rabbits
Tomography, X-Ray Computed
/ methods
Animal model
Atherosclerosis
Colchicine
Imaging
Inflammation
Plaque morphology
Journal
Journal of cardiovascular translational research
ISSN: 1937-5395
Titre abrégé: J Cardiovasc Transl Res
Pays: United States
ID NLM: 101468585
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
11
08
2019
accepted:
14
02
2020
pubmed:
7
3
2020
medline:
27
11
2021
entrez:
7
3
2020
Statut:
ppublish
Résumé
Colchicine demonstrated clinical benefits in the treatment of stable coronary artery disease. Our aim was to evaluate the effects of colchicine on atherosclerotic plaque stabilization. Atherosclerosis was induced in the abdominal aorta of 20 rabbits with high-cholesterol diet and balloon endothelial denudation. Rabbits were randomized to receive either colchicine or placebo. All animals underwent MRI,
Identifiants
pubmed: 32140929
doi: 10.1007/s12265-020-09974-7
pii: 10.1007/s12265-020-09974-7
doi:
Substances chimiques
Gout Suppressants
0
Colchicine
SML2Y3J35T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
150-160Références
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