Hyaluronic Acid Injections in the Treatment of Osteoarthritis Secondary to Primary Inflammatory Rheumatic Diseases: A Systematic Review and Qualitative Synthesis.
Humans
Hyaluronic Acid
/ administration & dosage
Inflammation
/ drug therapy
Injections, Intra-Articular
Osteoarthritis
/ drug therapy
Quality of Life
Rheumatic Diseases
/ complications
Synovial Fluid
/ drug effects
Synovitis
/ drug therapy
Treatment Outcome
Viscosupplements
/ administration & dosage
Hyaluronic acid
Osteoarthritis
Qualitative synthesis
Rheumatic diseases
Rheumatology
Systematic review
Viscosupplementation
Journal
Advances in therapy
ISSN: 1865-8652
Titre abrégé: Adv Ther
Pays: United States
ID NLM: 8611864
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
24
12
2019
pubmed:
7
3
2020
medline:
15
12
2020
entrez:
7
3
2020
Statut:
ppublish
Résumé
The purpose of this study is to review the current literature on the use of hyaluronic acid (HA) specifically applied to the treatment of osteoarthritis (OA) secondary to primary inflammatory rheumatic diseases. Osteoarthritis should be carefully considered because it has potentially devastating effects on health-related quality of life. Locally injected HA seems to be an effective treatment for OA but it is not clear how to place this treatment in the context of inflammatory rheumatic disorders. To retrieve relevant articles, we conducted the search through MEDLINE, EMBASE and Cochrane Databases performing the PICO strategy. We finally selected four randomized clinical trials and six observational studies and grouped them in accordance with its main objective within three focuses: the clinical effect of HA therapy in joints without any signs of inflammation, the clinical effects of HA therapy in joints with active synovitis, and the involvement and changes of synovial fluid in the treatment of secondary OA. Our qualitative analysis clearly showed that the current literature is marked by high levels of heterogeneity and therefore difficult to interpret. Therefore, our hypothesis that viscosupplementation should be considered as a treatment for chronic moderate symptomatic OA secondary to inflammatory rheumatic diseases, and not for flares with joint swelling, cannot be definitely supported. Well-designed studies are necessary to definitively clarify the range of application of intra-articular HA injections in the treatment of inflammatory rheumatic disorders.
Identifiants
pubmed: 32141016
doi: 10.1007/s12325-020-01256-7
pii: 10.1007/s12325-020-01256-7
pmc: PMC7140740
doi:
Substances chimiques
Viscosupplements
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Systematic Review
Langues
eng
Pagination
1347-1359Références
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