Incorporation of the Nonproteinogenic Amino Acid β-Methylamino-alanine Affects Amyloid β Fibril Properties and Toxicity.
Amyloid β toxicity
BMAA
amyloid dynamics
amyloid structure
nonproteinaceous amino acid mutation
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
pubmed:
7
3
2020
medline:
15
4
2021
entrez:
7
3
2020
Statut:
ppublish
Résumé
The nonproteinogenic amino acid β-methylamino alarelevant example for environmental hazards are nonnine (BMAA) is a neurotoxin and represents a potential risk factor for neurodegenerative diseases. Despite intense research over the last years, the pathological mechanism of BMAA is still unclear. One of the main open questions is whether BMAA can be misincorporated into proteins, especially as a substitute for serine, and whether this has structural and functional consequences for the afflicted proteins leading to early onset neurodegeneration. In this study, we hypothesize that BMAA was indeed incorporated into Aβ
Identifiants
pubmed: 32141731
doi: 10.1021/acschemneuro.9b00660
doi:
Substances chimiques
Amino Acids, Diamino
0
Amyloid
0
Amyloid beta-Peptides
0
Neurotoxins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM