Mohs Micrographic Surgery in Patients Younger Than 40 Years.
Adolescent
Adult
Age Factors
Aged
Australia
/ epidemiology
Biopsy
Carcinoma, Basal Cell
/ epidemiology
Carcinoma, Squamous Cell
/ epidemiology
Case-Control Studies
Female
Humans
Incidence
Male
Middle Aged
Mohs Surgery
/ methods
Patient Selection
Retrospective Studies
Skin
/ pathology
Skin Neoplasms
/ epidemiology
Young Adult
Journal
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
ISSN: 1524-4725
Titre abrégé: Dermatol Surg
Pays: United States
ID NLM: 9504371
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
7
3
2020
medline:
20
1
2021
entrez:
7
3
2020
Statut:
ppublish
Résumé
As the availability of Mohs micrographic surgery (MMS) continues to expand in Australia and incidence of keratinocyte cancer increases in adolescents and young adults, there has been rising interest in the use of MMS in this population. This study aimed to evaluate the characteristics of MMS cases in patients younger than 40 years. A review was performed of all MMS cases in patients younger than 40 years at the time of their surgery from 2012 to 2017 at the Skin and Cancer Foundation Australia, with comparison to a control group, aged older than 40 years. Patient, tumor and management characteristics were analyzed. Four hundred ninety-three cases were eligible. Study and control groups differed significantly regarding gender (p < .001), tumor pathology (p < .001), anatomic site of tumor (p < .001), Mohs surgery stages (p = .039), defect size (p < .001), and repair method (p < .001). Retrospective study at a single institution. Mohs micrographic surgery cases in patients younger than 40 years exhibit unique patient and tumor characteristics influencing choice of repair method.
Sections du résumé
BACKGROUND
As the availability of Mohs micrographic surgery (MMS) continues to expand in Australia and incidence of keratinocyte cancer increases in adolescents and young adults, there has been rising interest in the use of MMS in this population.
OBJECTIVE
This study aimed to evaluate the characteristics of MMS cases in patients younger than 40 years.
METHODS
A review was performed of all MMS cases in patients younger than 40 years at the time of their surgery from 2012 to 2017 at the Skin and Cancer Foundation Australia, with comparison to a control group, aged older than 40 years. Patient, tumor and management characteristics were analyzed.
RESULTS
Four hundred ninety-three cases were eligible. Study and control groups differed significantly regarding gender (p < .001), tumor pathology (p < .001), anatomic site of tumor (p < .001), Mohs surgery stages (p = .039), defect size (p < .001), and repair method (p < .001).
LIMITATIONS
Retrospective study at a single institution.
CONCLUSION
Mohs micrographic surgery cases in patients younger than 40 years exhibit unique patient and tumor characteristics influencing choice of repair method.
Identifiants
pubmed: 32141929
doi: 10.1097/DSS.0000000000002376
pii: 00042728-202012000-00002
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1481-1485Références
Hoc Task Force Ad, Connolly SM, Baker DR, Coldiron BM, et al. AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for mohs micrographic surgery: a report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery. J Am Acad Dermatol 2012;67:531–50.
Stewart TJ, Moreno Bonilla G, Venning VL, Lee S, et al. Mohs micrographic surgery at the skin and cancer foundation Australia, 20 years later (1997-2017). Dermatol Surg 2020;46:165–8.
Christenson LJ, Borrowman TA, Vachon CM, Tollefson MM, et al. Incidence of basal cell and squamous cell carcinoma in a population younger than 40 years. JAMA 2005;294:681–90.
Flohil S, Seubring I, van Rossum MM, Coebergh JWW, et al. Trends in basal cell carcinoma incidence rates: a 37-year Dutch observational study. J Invest Dermatol 2013;133:913–8.
Camamero-Mulas C, Delgado Jimenez Y, Sanmartin-Jimenez O, Farces JA, et al. Mohs micrographic surgery in the elderly: comparison of tumours, surgery and first-year follow-up in patients younger and older than 80 years old in REGEMOHS. J Eur Acad Dermatol Venereol 2018;31:108–12.
Quatrano NA, Mu EQ, Orbuch DE, Haimovic A, et al. Demographic and tumor characteristics of patients younger than 50 years with nonmelanoma skin cancer referred for Mohs micrographic surgery. J Drugs Dermatol 2018;17:499–505.
Dinehart SM, Dodge R, Stanley WE, Franks HH, et al. Basal cell carcinoma treated with Mohs surgery. A comparison of 54 younger patients with 1050 older patients. J Dermatol Surg Oncol 1992;18:560–6.
Boyd AS, Shyr Y, King LE Jr. Basal cell carcinoma in young women: an evaluation of the association of tanning bed use and smoking. J Am Acad Dermatol 2002;46:706–9.
Choi K, Lazovich D, Southwell, Forster J, et al. Prevalence and characteristics of indoor tanning use among men and women in the United States. Arch Dermatol 2010;14:1356–61.
Rutherford T, Elliot T, Vinciullo C. Mohs surgery in Australia: a survey of work practices. Australas J Dermatol 2011;52:98–103.
Campbell RM, Perlis CS, Malik MK, Dufresne RG Jr. Characteristics of Mohs practices in the United States: a recall survey of ACMS surgeons. Dermatol Surg 2007;22:1413–8.
Macfarlane L, Waters A, Evans A, Affleck A, et al. Seven years' experience of Mohs micrographic surgery in a UK centre, and development of a UK minimum dataset and audit standards. Clin Exp Dermatol 2013;38:262–9.
Stenquist B, Wennberg AM, Larko O. Mohs micrographic surgery in Gothenburg, Sweden. Acta Derm Venereol 2000;80:152.
Mina MA, Picariello A, Fewkes JL. Superficial basal cell carcinomas of the head and neck. Dermatol Surg 2013;39:1003–8.
Gray DT, Suman VJ, Su WP, Clay RP, et al. Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992. Arch Dermatol 1997;133:735.
Brash DE, Rudolph JA, Simon JA, Lin A, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 1991;88:10124.
Nadimi AE, Zhou Y, Ahn J, Hendi A. Facial basal cell carcinoma in patients younger than 40. J Drugs Dermatol 2018;17:525–30.
Stewart TJ, Saunders A. Risk factors for positive margins after wide local excision of cutaneous squamous cell carcinoma. J Dermatolog Treat 2018;29:706–8.
Ryu SH, Hyn Joo Y, Kim SO, Park KC, et al. Influence of age and regional differences on skin elasticity as measured by the cutometer. Skin Res Technol 2008;14:354–8.
Alam M, Berg D, Bhati A, Cohen JL, et al. Association between number of stages in Mohs micrographic surgery and surgeon-, patient- and tumor-specific features a cross-sectional study of practice patterns of 20 early- and mid-career mohs surgeons. Dermatol Surg 2010;36:1915–20.
Santos-Arroyo A, Carrasquillo OY, Cardona R, Sanchez JL, et al. Non-melanoma skin cancer tumor's characteristics and histologic subtype as a predictor for subclinical spread and number of mohs stages required to achieve tumour-free margins. P R Health Sci J 2019;38:40–5.
Sahai S, Walling HW. Factors predictive of complex Mohs surgery cases. J Dermatolog Treat 2012;23:421–7.
Ibrahim AM, Rabie AN, Borud L, Tobias AM, et al. Common patterns of reconstruction for Mohs defects in the head and neck. J Craniofac Surg 2014;25:87–92.