Regulation of the RNAPII Pool Is Integral to the DNA Damage Response.

DNA Damage DNA Repair HEK293 Cells Humans RNA Polymerase II / metabolism Saccharomyces cerevisiae / metabolism Saccharomyces cerevisiae Proteins / metabolism Transcription, Genetic Ubiquitination Ultraviolet Rays
DNA damage RNA polymerase II UV irradiation transcription ubiquitin ubiquitylation

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
19 03 2020
Historique:
received: 22 07 2019
revised: 23 12 2019
accepted: 04 02 2020
pubmed: 7 3 2020
medline: 21 10 2020
entrez: 7 3 2020
Statut: ppublish

Résumé

In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown. Here, we provide insight into how these responses are connected by the finding that ubiquitylation of RNAPII itself, at a single lysine (RPB1 K

Identifiants

DOI: 10.1016/j.cell.2020.02.009 PMID: 32142654 PMC: PMC7103762
pubmed: 32142654
pii: S0092-8674(20)30153-7
doi: 10.1016/j.cell.2020.02.009
pmc: PMC7103762
pii:
doi:

Substances chimiques

Saccharomyces cerevisiae Proteins 0
RNA Polymerase II EC 2.7.7.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1245-1261.e21

Subventions

Organisme : Cancer Research UK
ID : FC001166
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001166
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001166
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 1099160
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Ana Tufegdžić Vidaković (A)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Richard Mitter (R)

Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Gavin P Kelly (GP)

Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Michelle Neumann (M)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Michelle Harreman (M)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Marta Rodríguez-Martínez (M)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Anna Herlihy (A)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Juston C Weems (JC)

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

Stefan Boeing (S)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Vesela Encheva (V)

Protein Analysis and Proteomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Liam Gaul (L)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Laura Milligan (L)

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland.

David Tollervey (D)

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland.

Ronald C Conaway (RC)

Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Joan W Conaway (JW)

Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Ambrosius P Snijders (AP)

Protein Analysis and Proteomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Aengus Stewart (A)

Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Jesper Q Svejstrup (JQ)

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: jesper.svejstrup@crick.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Regulation of the RNAPII Pool Is Integral to...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Regulation of the RNAPII Pool Is Integral to...