Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop.
Clinical trials
Dupilumab
Mepolizumab
Nasal polyposis
Omalizumab
Outcomes
Rhinosinusitis
Type 2 inflammation
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
18
02
2020
revised:
25
02
2020
accepted:
25
02
2020
pubmed:
7
3
2020
medline:
15
5
2021
entrez:
7
3
2020
Statut:
ppublish
Résumé
The development of biologics targeting various aspects of type 2 inflammation for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) will provide clinicians with powerful tools to help treat these patients. However, other therapies are also available, and positioning of biologics in a management algorithm will require comparative trials. In November 2019, the National Institute of Allergy and Infectious Diseases convened a workshop to consider potential future trial designs. Workshop participants represented a wide spectrum of clinical specialties, including otolaryngology, allergy, and pulmonary medicine, as well as expertise in CRSwNP pathophysiology and in trial methodology and statistics. The workshop discussed the current state of knowledge in CRSwNP and considered the advantages and disadvantages of various clinical trial or observational study designs and various clinical outcomes. The output from this workshop, which is presented in this report, will hopefully provide investigators with adequate information and ideas to design future studies and answer critical clinical questions. It will also help clinicians understand the current state of the management of CRSwNP and its gaps and be more able to interpret the new information to come.
Identifiants
pubmed: 32142964
pii: S2213-2198(20)30183-5
doi: 10.1016/j.jaip.2020.02.023
pmc: PMC8177483
mid: NIHMS1704841
pii:
doi:
Substances chimiques
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1532-1549.e1Subventions
Organisme : NIAID NIH HHS
ID : P01 AI145818
Pays : United States
Organisme : NIDCD NIH HHS
ID : T32 DC000022
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
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