Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina.

Aquaporin-4 Autoimmunity Myelin-oligodendrocyte-glycoprotein Neuromyelitis optica spectrum disorder Optic nerve Retina

Journal

Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498

Informations de publication

Date de publication:
20 Feb 2020
Historique:
received: 17 12 2019
revised: 04 02 2020
accepted: 18 02 2020
pubmed: 7 3 2020
medline: 7 3 2020
entrez: 7 3 2020
Statut: aheadofprint

Résumé

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups. Transfer of total IgG from a MOG-IgG positive patient to 2D2 mice did neither enhance disability nor induce functional or histological alterations in the retina.

Identifiants

DOI: 10.1016/j.jneuroim.2020.577194 PMID: 32143071
pubmed: 32143071
pii: S0165-5728(19)30651-4
doi: 10.1016/j.jneuroim.2020.577194
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

577194

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing interests relevant to the content of this manuscript.

Auteurs

Simon Faissner (S)

Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany. Electronic address: simon.faissner@rub.de.

Florian Graz (F)

Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.

Sabrina Reinehr (S)

Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.

Laura Petrikowski (L)

Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.

Steffen Haupeltshofer (S)

Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany.

Ulaş Ceylan (U)

Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany.

Gesa Stute (G)

Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.

Stephan Winklmeier (S)

Institute of Clinical Neuroimmunology, Ludwig-Maximilians-Universität München, Munich, Germany.

Florence Pache (F)

Department of Neurology, Charité - Universitaetsmedizin Berlin, Berlin, Germany.

Friedemann Paul (F)

Department of Neurology, Charité - Universitaetsmedizin Berlin, Berlin, Germany; NeuroCure Clinical Research Center und Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité - Universitaetsmedizin Berlin, Berlin, Germany.

Klemens Ruprecht (K)

Department of Neurology, Charité - Universitaetsmedizin Berlin, Berlin, Germany.

Edgar Meinl (E)

Institute of Clinical Neuroimmunology, Ludwig-Maximilians-Universität München, Munich, Germany.

H Burkhard Dick (HB)

Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.

Ralf Gold (R)

Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany.

Ingo Kleiter (I)

Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany; Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg, Germany.

Stephanie C Joachim (SC)

Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany; Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, 44791 Bochum, Germany. Electronic address: stephanie.joachim@rub.de.

Classifications MeSH