TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models.
application in cancer
conjunctival melanoma
in vitro and in vivo models
photodynamic therapy
zebrafish tumour model
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Mar 2020
04 Mar 2020
Historique:
received:
31
01
2020
revised:
27
02
2020
accepted:
29
02
2020
entrez:
8
3
2020
pubmed:
8
3
2020
medline:
8
3
2020
Statut:
epublish
Résumé
The ruthenium-based photosensitizer (PS) TLD1433 has completed a phase I clinical trial for photodynamic therapy (PDT) treatment of bladder cancer. Here, we investigated a possible repurposing of this drug for treatment of conjunctival melanoma (CM). CM is a rare but often deadly ocular cancer. The efficacy of TLD1433 was tested on several cell lines from CM (CRMM1, CRMM2 and CM2005), uveal melanoma (OMM1, OMM2.5, MEL270), epidermoid carcinoma (A431) and cutaneous melanoma (A375). Using 15 min green light irradiation (21 mW/cm
Identifiants
pubmed: 32143295
pii: cancers12030587
doi: 10.3390/cancers12030587
pmc: PMC7139549
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA222227
Pays : United States
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