Severe Infection in Anti-Glomerular Basement Membrane Disease: A Retrospective Multicenter French Study.
ANCA
age
anti-GBM disease
infection
survival
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
04 Mar 2020
04 Mar 2020
Historique:
received:
19
02
2020
revised:
27
02
2020
accepted:
28
02
2020
entrez:
8
3
2020
pubmed:
8
3
2020
medline:
8
3
2020
Statut:
epublish
Résumé
In patients presenting with anti-glomerular basement membrane (GBM) disease with advanced isolated kidney involvement, the benefit of intensive therapy remains controversial due to adverse events, particularly infection. We aim to describe the burden of severe infections (SI) (requiring hospitalization or intravenous antibiotics) and identify predictive factors of SI in a large cohort of patients with anti-GBM disease. Among the 201 patients (median [IQR] age, 53 [30-71] years) included, 74 had pulmonary involvement and 127 isolated glomerulonephritis. A total of 161 SI occurred in 116 patients during the first year after diagnosis. These infections occurred during the early stage of care (median [IQR] time, 13 [8-19] days after diagnosis) with mainly pulmonary (45%), catheter-associated bacteremia (22%) and urinary tract (21%) infections. In multivariable analysis, positive ANCA (HR [95\% CI] 1.62 [1.07--2.44];
Identifiants
pubmed: 32143501
pii: jcm9030698
doi: 10.3390/jcm9030698
pmc: PMC7141378
pii:
doi:
Types de publication
Journal Article
Langues
eng
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