In vitro anti-HIV activity of some Indian medicinal plant extracts.
Achyranthes aspera
HIV
PM1
Rosa centifolia
TZM-b1
Journal
BMC complementary medicine and therapies
ISSN: 2662-7671
Titre abrégé: BMC Complement Med Ther
Pays: England
ID NLM: 101761232
Informations de publication
Date de publication:
06 Mar 2020
06 Mar 2020
Historique:
received:
18
07
2019
accepted:
15
01
2020
entrez:
8
3
2020
pubmed:
8
3
2020
medline:
5
9
2020
Statut:
epublish
Résumé
Human Immunodeficiency Virus (HIV) persists to be a significant public health issue worldwide. The current strategy for the treatment of HIV infection, Highly Active Antiretroviral Therapy (HAART), has reduced deaths from AIDS related disease, but it can be an expensive regime for the underdeveloped and developing countries where the supply of drugs is scarce and often not well tolerated, especially in persons undergoing long term treatment. The present therapy also has limitations of development of multidrug resistance, thus there is a need for the discovery of novel anti-HIV compounds from plants as a potential alternative in combating HIV disease. Ten Indian medicinal plants were tested for entry and replication inhibition against laboratory adapted strains HIV-1 The methanolic extracts of Achyranthes aspera, Rosa centifolia and aqueous extract of Ficus benghalensis inhibited laboratory adapted HIV-1 strains (IC These active methanolic extracts of Achyranthes aspera and Rosa centifolia, could be further subjected to chemical analysis to investigate the active moiety responsible for the anti-HIV activity. Methanolic extract of Rosa centifolia was found to be well tolerated maintaining the epithelial integrity of HEC-1A cells in vitro and thus has potential for investigating it further as candidate microbicide.
Sections du résumé
BACKGROUND
BACKGROUND
Human Immunodeficiency Virus (HIV) persists to be a significant public health issue worldwide. The current strategy for the treatment of HIV infection, Highly Active Antiretroviral Therapy (HAART), has reduced deaths from AIDS related disease, but it can be an expensive regime for the underdeveloped and developing countries where the supply of drugs is scarce and often not well tolerated, especially in persons undergoing long term treatment. The present therapy also has limitations of development of multidrug resistance, thus there is a need for the discovery of novel anti-HIV compounds from plants as a potential alternative in combating HIV disease.
METHODS
METHODS
Ten Indian medicinal plants were tested for entry and replication inhibition against laboratory adapted strains HIV-1
RESULTS
RESULTS
The methanolic extracts of Achyranthes aspera, Rosa centifolia and aqueous extract of Ficus benghalensis inhibited laboratory adapted HIV-1 strains (IC
CONCLUSION
CONCLUSIONS
These active methanolic extracts of Achyranthes aspera and Rosa centifolia, could be further subjected to chemical analysis to investigate the active moiety responsible for the anti-HIV activity. Methanolic extract of Rosa centifolia was found to be well tolerated maintaining the epithelial integrity of HEC-1A cells in vitro and thus has potential for investigating it further as candidate microbicide.
Identifiants
pubmed: 32143607
doi: 10.1186/s12906-020-2816-x
pii: 10.1186/s12906-020-2816-x
pmc: PMC7076815
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69Subventions
Organisme : Department of Biotechnology , Ministry of Science and Technology
ID : BT/PR7965/Med/14/1203/2006
Organisme : Department of Biotechnology , Ministry of Science and Technology
ID : BT/PR7965/Med/14/1203/2006, Dated 20 Oct 2006
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