Formation, interpretation, and regulation of the Drosophila Dorsal/NF-κB gradient.
Animals
Body Patterning
Computational Biology
/ methods
Drosophila Proteins
/ genetics
Drosophila melanogaster
/ embryology
Embryo, Nonmammalian
/ cytology
Gene Expression Regulation, Developmental
NF-kappa B
/ genetics
Nuclear Proteins
/ genetics
Phosphoproteins
/ genetics
Signal Transduction
Transcription Factors
/ genetics
Cactus
Computational modeling
Gene expression
Morphogen
Quantitative imaging
Twist
Zelda
Journal
Current topics in developmental biology
ISSN: 1557-8933
Titre abrégé: Curr Top Dev Biol
Pays: United States
ID NLM: 0163114
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
8
3
2020
pubmed:
8
3
2020
medline:
4
6
2021
Statut:
ppublish
Résumé
The morphogen gradient of the transcription factor Dorsal in the early Drosophila embryo has become one of the most widely studied tissue patterning systems. Dorsal is a Drosophila homolog of mammalian NF-κB and patterns the dorsal-ventral axis of the blastoderm embryo into several tissue types by spatially regulating upwards of 100 zygotic genes. Recent studies using fluorescence microscopy and live imaging have quantified the Dorsal gradient and its target genes, which has paved the way for mechanistic modeling of the gradient. In this review, we describe the mechanisms behind the initiation of the Dorsal gradient and its regulation of target genes. The main focus of the review is a discussion of quantitative and computational studies of the Dl gradient system, including regulation of the Dl gradient. We conclude with a discussion of potential future directions.
Identifiants
pubmed: 32143742
pii: S0070-2153(19)30094-8
doi: 10.1016/bs.ctdb.2019.11.007
pii:
doi:
Substances chimiques
Drosophila Proteins
0
NF-kappa B
0
Nuclear Proteins
0
Phosphoproteins
0
Transcription Factors
0
dl protein, Drosophila
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
143-191Informations de copyright
© 2020 Elsevier Inc. All rights reserved.