Epstein-Barr virus-associated large B-cell lymphoma transformation in marginal zone B-cell lymphoma: a series of four cases.
DLBCL
EBV
MZL
progression
transformation
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
04
12
2019
revised:
07
02
2020
accepted:
02
03
2020
pubmed:
8
3
2020
medline:
7
4
2021
entrez:
8
3
2020
Statut:
ppublish
Résumé
To present four examples of clonally related Epstein-Barr virus (EBV)-associated large-cell transformation of marginal zone lymphoma (MZL) (of nodal, extranodal and splenic types), occurring 120, 11 and 5 months after the initial diagnosis in three instances, and concurrently in one case; and to discuss several interesting features of EBV infection. Somatic mutations were detected by use of a customised panel for next-generation sequencing and polymerase chain reaction studies of IgH in both low-grade and high-grade components of each case. In case 1, the initial biopsy of nodal MZL showed scattered EBV-positive cells, which might constitute an indication of EBV-induced progression. Case 2 showed heterogeneous EBV expression, a phenomenon attributable to loss of the EBV episomes during cell division, or to a secondary superinfection or reactivation of the virus. In case 3, p53 overexpression related to gene mutation and EBV-encoded small RNAs were identified in the same neoplastic component. In case 4, the mucosa-associated lymphoid tissue-type MZL and the high-grade component were identified concurrently in a patient previously treated with methotrexate for an autoimmune disorder. These data suggest that the presence of EBV should be added to the list of potential markers to be analysed for MZL prognosis.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-122Subventions
Organisme : Ministerio de Economía y Competitividad
ID : SAF2013-47416-R
Organisme : Ministerio de Economía y Competitividad
ID : RD06/0020/0107
Organisme : Ministerio de Economía y Competitividad
ID : RD012/0036/0060
Organisme : Ministerio de Economía y Competitividad
ID : PI17/2172
Organisme : Ministerio de Economía y Competitividad
ID : PI16/01294
Organisme : Ministerio de Economía y Competitividad
ID : PIE15/0081
Organisme : Instituto de Salud Carlos III
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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