Comparison of live donor predonation and post-transplant kidney volumes and glomerular size in pediatric patients weighing less than 15 kg - a retrospective study.
donation kidney
graft function
pediatric renal transplantation
small children
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
02
09
2019
revised:
18
10
2019
accepted:
02
03
2020
pubmed:
8
3
2020
medline:
25
6
2021
entrez:
8
3
2020
Statut:
ppublish
Résumé
Renal transplantation of adult-size kidneys presents a size mismatch in small children. This study presents a comparison of live donor predonation and recipient post-transplant kidney volumes (k-vol) and glomerular size at 1 year after transplantation. We analyzed 47 pediatric renal transplant recipients weighing <15 kg between 2009 and 2017. The k-vol before and 1 year after transplantation and glomerular size at implant and 1 year post-transplant were evaluated. We estimated the relationships between these changes and graft function, and the factors associated with k-vol. Pretransplant k-vol was 158.1 ± 25.1 ml, and the k-vol at 1 year post-transplant was significantly reduced by -17.2% to 132.3 ± 27.3 ml (P < 0.001). Implant glomerular size showed the diameter was 165.3 ± 15.1 µm and the area 20 737.1 ± 3230.6 µm
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
878-886Informations de copyright
© 2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd.
Références
NAPRTCS 2014 Annual Transplant Report. https://web.emmes.com/study/ped/annlrept/annlrept.html.
Humar A, Sharpe J, Hollomby D. Salvage of a renal allograft with renal vein occlusion secondary to extrinsic compression. Am J Kidney Dis 1996; 28: 622.
Ball CG, Kirkpatrick AW, Yilmaz S, Monroy M, Nicolaou S, Salazar A. Renal allograft compartment syndrome: an underappreciated postoperative complication. Am J Surg 2006; 191: 619.
Damiano G, Maione C, Maffongelli A, et al. Renal allograft compartment syndrome: is it possible to prevent? Transpl Proc 2016; 48: 340.
Muramatsu M, Mizutani T, Hamasaki Y, et al. Transplantation of adult-size kidneys in small pediatric recipients: a single-center experience. Pediatr Transplant 2019; 23: e13401.
Yanishi M, Kinoshita H, Yoshida T, et al. Comparison of live donor pre-transplant and recipient post-transplant renal volumes. Clin Transplant 2016; 30: 613.
Salvatierra O Jr, Singh T, Shifrin R, et al. Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow. Transplantation 1998; 66: 819.
Gholami S, Sarwal MM, Naesens M, et al. Standardizing resistive indices in healthy pediatric transplant recipients of adult-sized kidneys. Pediatr Transplant 2010; 14: 126.
Cheng H, Dong HR, Lin RQ, Sun LJ, Chen YP. Determination of normal value of glomerular size in Chinese adults by different measurement methods. Nephrology 2012; 17: 488.
Uemura O, Nagai T, Ishikura K, et al. Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease. Clin Exp Nephrol 2014; 18: 626.
Salvatierra O Jr, Millan M, Concepcion W. Pediatric renal transplantation with considerations for successful outcomes. Semin Pediatr Surg 2006; 15: 208.
Moore L, Williams R, Staples A. Glomerular dimensions in children under 16 years of age. J Pathol 1993; 171: 145.
Alperovich G, Maldonado R, Moreso F, Fulladosa X, Grinyo JM, Seron D. Glomerular enlargement assessed by paired donor and early protocol renal allograft biopsies. Am J Transplant 2004; 4: 650.
Naesens M, Kambham N, Concepcion W, Salvatierra O Jr, Sarwal M. The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients. Am J Transplant 2007; 7: 2504.
Sarwal MM, Cecka JM, Millan MT, Salvatierra O Jr. Adult-size kidneys without acute tubular necrosis provide exceedingly superior long-term graft outcomes for infants and small children: a single center and UNOS analysis. United Netw Organ Sharing Transplant 2000; 70: 1728.
Salvatierra O, Concepcion W, Sarwal M. A critical look at the immunologically favorable adult-sized kidney transplant in small children. Pediatr Transplant 2009; 13: 265.
Giuliani S, Gamba PG, Chokshi NK, Gasparella P, Murer L, Zanon GF. The effect of donor/recipient body surface area ratio on outcomes in pediatric kidney transplantation. Pediatr Transplant 2009; 13: 290.
Provoost AP, van Aken M. Renal adaptation to additional nephrons: a functional study in the three-kidney rat. Ren Physiol 1985; 8: 129.
Bohlin AB, Berg U. Renal functional adaptation of the adult kidney following transplantation to the child. Kidney Int 1991; 39: 129.
Pape L, Offner G, Ehrich JH, de Boer J, Persijn GG. Renal allograft function in matched pediatric and adult recipient pairs of the same donor. Transplantation 2004; 77: 1191.
Dubourg L, Cochat P, Hadj-Aissa A, Tyden G, Berg UB. Better long-term functional adaptation to the child's size with pediatric compared to adult kidney donors. Kidney Int 2002; 62: 1454.
Salvatierra O Jr, Sarwal M. Renal perfusion in infant recipients of adult-sized kidneys is a critical risk factor. Transplantation 2000; 70: 412.
Saxena AB, Busque S, Arjane P, Myers BD, Tan JC. Preoperative renal volumes as a predictor of graft function in living donor transplantation. Am J Kidney Dis 2004; 44: 877.