Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model.
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
received:
02
01
2019
revised:
22
01
2020
accepted:
27
01
2020
pubmed:
8
3
2020
medline:
15
5
2021
entrez:
8
3
2020
Statut:
ppublish
Résumé
Biological tissues contain micrometer-scale gaps and pores, including those found within extracellular matrix fiber networks, between tightly packed cells, and between blood vessels or nerve bundles and their associated basement membranes. These spaces restrict cell motion to a single-spatial dimension (1D), a feature that is not captured in traditional in vitro cell migration assays performed on flat, unconfined two-dimensional (2D) substrates. Mechanical confinement can variably influence cell migration behaviors, and it is presently unclear whether the mechanisms used for migration in 2D unconfined environments are relevant in 1D confined environments. Here, we assessed whether a cell migration simulator and associated parameters previously measured for cells on 2D unconfined compliant hydrogels could predict 1D confined cell migration in microfluidic channels. We manufactured microfluidic devices with narrow channels (60-μm
Identifiants
pubmed: 32145191
pii: S0006-3495(20)30163-6
doi: 10.1016/j.bpj.2020.01.048
pmc: PMC7136340
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1709-1720Subventions
Organisme : NCI NIH HHS
ID : U54 CA210190
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA172986
Pays : United States
Informations de copyright
Copyright © 2020 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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